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Josef Coresh, MD

  • George W. Comstock Professor
  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

2024 E. Monument Street, Room 2-635
Suite 2-600
Baltimore, Maryland 21287

410-955-0495
410 955-0476

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Education

MD, Johns Hopkins School of Medicine, 1992
PhD, Johns Hopkins Bloomberg School of Public Health, 1992
MHS, Johns Hopkins Bloomberg School of Public Health, 1992

Overview

I study risk factors for vascular disease across different organs including the heart, kidney and brain with the goal of improving health and training leaders in research. Much of my work has focused on factors mediating excess risk among patients with various stages of chronic kidney disease (CKD), from pre-clinical to end-stage.  Rigorously defining the burden of CKD in the population is an area I have contributed to since co-chairing the guidelines workgroup which standardized CKD staging (chair, Andrew Levey).  I have enjoyed looking at genetic and biologic risk factors as well as innovative epidemiologic methods and statistical analysis in the conduct of this research. The ultimate objective of my work is to decrease the enormous burden of vascular disease through developing the scientific basis for behavioral and pharmacologic interventions.

Epidemiology and clinical research is most productive when done collaboratively.  I am fortuante to play a leadership role in a number of large collaborations.  Our department, Welch Center and university (Comstock Professorship) produced short videos which partly feature my work and thinking about training future leaders.

Program leadership at Hopkins:

Director, Cardiovascular Epidemiology Training Program (T32HL07024) and co-director area of concentration.

Director, George W. Comstock Center for Public Health Research and Prevention (GWCC) with over 30 staff members involved in data collection based in Hagerstown, MD.   

Research projects include leadership roles in:

 Atherosclerosis Risk in Communities Study (ARIC) - A prospective study of 15,792 individuals recruited in 1986-1988 and followed for 30+ years for cardiovascular disease and a wide range of other conditions. This NHLBI funded multi-center contract provides the basis for a wide range of ancillary studies which now average over 150 publications annually. Visit 7 is underway (2017-2018) and future visits are being planned.

Kidney Disease Collaborative Studies - Co-chairing the National Kidney Foundation guidelines on the definition and classification of kidney disease led to an ongoing line of research.

Chronic Kidney Disease Prognosis Consortium (CKD-PC) - Analyzing data from ~80 cohorts across >40 countries including over 10 Million individuals.

CKD-EPI Collaboration - The 2009 CKD-EPI Creatinine Equation is replacing the MDRD Study equation as the most widely used equation to estimate GFR globally. Additional studies focus on discovery and validation of novel markers for CKD staging and progression. Recent efforts are focused on novel methods for improved GFR estimation (provisional patent submitted 2014).

CKD Biomarkers Consortium - Explores a wide range of markers by multiple groups in a NIDDK U01 grant. Hopkins is now focusing on metabolomics in CKD. 

NHANES Kidney Disease Studies - Ongoing efforts to provide the most valid estimates of kidney disease prevalence in the U.S. as well as examine concurrent complications and consequences.  

National committees: My role as vice-chair of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (KDOQI) workgroup for the Clinical Practice Guideline “Chronic Kidney Disease: Evaluation, Classification and Stratification” has lead to ongoing involvement in the international effort to address the public health burden of chronic kidney disease. This has included contributing to Kidney Disease Improving Global Outcomes(KDIGO) initiative planning controversies meetings in 2004 and 2009 and new guidelines in 2013. Likewise, the NKF-FDA-EMA joint initiatives for improving intermediate outcomes of CKD progression in clinical trials was informed by our work in 2013 and 2018.

Honors and Awards

2014-present        Thomson Reuters Highly Cited Researchers: World’s leading scientific minds top 1% most influential researchers in the world.

2015                  National Kidney Foundation (NKF) David M. Hume Memorial Award - highest honor given to a distinguished scientist-clinician in the field of kidney and urologic diseases

2012                  Inaugural George W Comstock Professor – Johns Hopkins University Endowed chair

2012           David M. Levine Excellence in Mentoring Award – Johns Hopkins School of Medicine 

2010           American Heart Association (AHA) Epidemiology and Prevention Mentoring Award

2010                  National Kidney Foundation (NKF) Garabed Eknoyan Award - Making Lives Better for people with kidney disease  

2010                  Co-author on 2009 PNAS paper Cozzarelli Prize for outstanding scientific excellence and originality “Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout” by Owen M. Woodward, Anna Köttgen, Josef Coresh, Eric Boerwinkle, William B. Guggino, and Michael Köttgen

2005                  American Epidemiological Society (AES) membership

1998, 2001,2015 Advising, Mentoring & Teaching Recognition Award, JHSPH

1987                  Medical Scientist Training Program Award, JHU

 

1986                  Princeton University - Phi Beta Kappa, Magna Cum Laude (George B. Wood Legacy Prize - highest academic standing for junior year at Princeton University)

  • Epidemiology
  • Cardiovascular Disease
  • Kidney Disease
  • Biomarkers
  • Dementia
  • Hearing Loss
  • Metabolomics
  • Proteomics
  • Genetic Epidemiology

Pubmed has the latest information [>700 entries cited >90,000 times].

  • Frequently cited kidney disease papers:
    1. Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G. National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003, Jul 15. Epub Date: 2003/07/16; 139(2): 137-47. Pub Med PMID: 12859163. [Summary of full guidelines published AJKD 2002; 39(2 Suppl 1):S1-S266. Pub Med PMID: 11904577]. Times Cited ~ 9253+3044=12,297
    2. Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F, Levey AS. Prevalence of chronic kidney disease in the United States. JAMA. 2007; 298(17): 2038-47. Pub Med PMID: 17986697. Times Cited ~ 3,155
    3. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro* AF, 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150(9): 604-12. Pub Med PMID: 19414839; PMCID: PMC2763564. Times Cited ~ 7,914
    4. CKD-PC, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis. Lancet. 2010; 375(9731): 2073-81. Pub Med PMID: 20483451; PMCID: PMC3993088. [Coresh J – CKD-PC steering committee chair]. Times Cited ~ 1,848
    5. Coresh J, Turin TC, Matsushita K, Sang Y, Ballew SH, Appel LJ, Arima H, Chadban SJ, Cirillo M, Djurdjev O, Green JA, Heine GH, Inker LA, Irie F, Ishani A, Ix JH, Kovesdy CP, Marks A, Ohkubo T, Shalev V, Shankar A, Wen CP, de Jong PE, Iseki K, Stengel B, Gansevoort RT, Levey AS. Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality. JAMA. 2014; 311(24): 2518-31. Pub Med PMID: 24892770; PMCID: PMC4172342.. Times cited ~ 288
  • Selected recent papers:
    1. Coresh J, Inker LA, Sang Y, Chen J, Shafi T, Post WS, Shlipak MG, Ford L, Goodman K, Perichon R, Greene T, Levey AS. Metabolomic profiling to improve glomerular filtration rate estimation: a proof-of-concept study. Nephrol Dial Transplant. 2018 Apr 30. doi: 10.1093/ndt/gfy094.
    2. Selvin E, Wang D, Matsushita K, Grams ME, Coresh J. Prognostic Implications of Single-Sample Confirmatory Testing for Undiagnosed Diabetes: A Prospective Cohort Study. Ann Intern Med. 2018 Aug 7;169(3):156-164.
    3. Grams ME, Coresh J. Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate. Kidney Int. 2018 Jun;93(6):1442-1451
  • Selected paper on dementia and cognition:
    Alonso A, Mosley T, Gottesman R, Catellier D, Sharrett AR, Coresh J.  Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study.J Neurol Neurosurg Psychiatry. 2009; 80(11):1194-201.
    Schneider AL, Sharrett AR, Patel MD, Alonso A, Coresh J, Mosley T, Selnes O, Selvin E, Gottesman RF. Education and cognitive change over 15 years: the atherosclerosis risk in communities study. J Am Geriatr Soc. 2012; 60(10):1847-53.
    Gottesman RF, Schneider AL, Zhou Y, Coresh J, Green E, Gupta N, Knopman DS, Mintz A, Rahmim A, Sharrett AR, Wagenknecht LE, Wong DF, Mosley TH. Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition. JAMA. 2017, Apr 11. 317(14): 1443-50. Pub Med PMID: 28399252.
    Gottesman RF, Albert MS, Alonso A, Coker LH, Coresh J, Davis SM, Deal JA, McKhann GM, Mosley TH, Sharrett AR, Schneider ALC, Windham BG, Wruck LM, Knopman DS. Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort. JAMA Neurol. 2017, Oct 01. 74(10): 1246-54. Pub Med PMID: 28783817.