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Lawrence J. Appel, MD

  • Professor

Departmental Affiliations

Center & Institute Affiliations

Contact Information

Welch Center for Prevention
2024 E. Monument Street, Room 2-600
Baltimore, Maryland 21287

410-955-4156
410-955-0476

Welch Center for Prevention, Epidemiology and Clinical Research

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Education

MPH, Johns Hopkins Bloomberg School of Public Health, 1989
MD, New York University School of Medicine, 1981

Overview

I am currently Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a large interdisciplinary research unit that bridges the Schools of Medicine and Public Health at Hopkins.  The mission of the Welch Center is to conduct epidemiologic, clinical and translational research of the highest quality and to train the next generation of interdisciplinary researchers. 

As for my own research, I have conducted clinical research with a particular focus on preventing blood pressure-related cardiovascular and kidney diseases. I have fopur active lines of research: (1) controlled feeding studies, (2) behavioral intervention trials, that test novel strategies to accomplish lifestyle changes, often related to obesity, (3) cohort studies and trials related to chronic kidney disease and its consequences, and (4) global implementation initiatives to prevent and control hypertension. A particularly notable feature of my research is the focus on conditions and diseases that disproportionately afflict minorities and on interventions that have the potential to substantially reduce racial disparities.

Over the course of my career, I have mentored numerous students, fellows and faculty (and continue to do so).  In addition, I serve as PI of the 1) Renal Disease Epidemiology T32 training grant and 2) Associate Director of the Behavioral Research in Heart and Vascular Disease T32 at Hopkins. Training a diverse cadre of individuals is one of the most enjoyable aspects of my career. As a reflection of my commitment to education, I have received numerous teaching and mentoring awards.

Honors and Awards

2018 Distinguished Scientist, American Heart Association

2016-20 Most Influential Scientists (top 1% of highly cited papers), awarded by Clarivate (Web of Science)

2016 Marvin Moser Clinical Hypertension Award from the American Society of Hypertension

2016 Women Faculty Sponsorship Award, from the Task Force on Women’s Academic Careers in Medicine, JHUSOM

2015 Advising, Mentoring, and Teaching Recognition Award (AMTRA), nominated by JHSPH student body

2015 Elected Member, Association of American Physicians (AAP)

2012 Elected Member, National Academy of Medicine (previously, Institute of Medicine, IOM)

2010 Director, Welch Center for Prevention, Epidemiology and Clinical Research

2010 Conner Award Lecturer, American Heart Association 

2010 Member, 2010 USDA/HHS Dietary Guidelines Advisory Committee

2008 David M. Levine Excellence in Mentoring Award

  • Cardiovascular disease
  • Kidney disease
  • Hypertension
  • Blood pressure
  • Diet
  • Lifestyle modifications
  • Fall prevention
  • Clinical trials

Selected publications from > 400

  • Appel LJ, Moore TL, Obarzanek E et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997 Apr 17;336(16):1117-24. PMID: 9099655.
  • Appel LJ, Sacks FM, Carey V et al for the OmniHeart Collaborative Research Group. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial. JAMA. 2005 Nov 16;294(19):2455-64. PMID: 16287956.
  • Appel LJ, Brands MW , Daniels SR et all American Heart Association. Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension. 2006 Feb;47(2):296-308. PMID: 16434724.
  • Appel LJ, Wright JT, Greene T, et al.  Intensive blood-pressure control in hypertensive chronic kidney disease.  N Engl J Med 2010:363(10):918-929.  PMID: 20818902
  • Cogswell ME, Loria CM, Terry AL, Zhao L, Wang CY, Chen TC, Wright JD, Pfeiffer CM, Merritt R, Moy CS, Appel LJ. Estimated 24-Hour Urinary Sodium and Potassium Excretion in US Adults. JAMA. 2018 Mar 7. doi: 10.1001/jama.2018.1156. PMID: 29516104.