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Biochemistry and Molecular Biology

Recent Publications

2018

Abraham R, McPherson RL, Sreekumar E, Leung AKL, Griffin DE. Preparation of Recombinant Alphaviruses for Functional Studies of ADP-Ribosylation. Methods Mol Biol. 2018;1813:297-316. PubMed PMID: 30097877. 

McPherson RL, Ong SE, Leung AKL. Quantitative Determination of MAR Hydrolase Residue Specificity In Vitro by Tandem Mass Spectrometry. Methods Mol Biol. 2018;1813:271-283. PubMed PMID: 30097875. 

Alexander EJ, Ghanbari Niaki A, Zhang T, Sarkar J, Liu Y, Nirujogi RS, Pandey A, Myong S, Wang J. Ubiquilin 2 modulates ALS/FTD-linked FUS-RNA complex dynamics and stress granule formation. Proc Natl Acad Sci U S A. 2018 Nov 15. PubMed PMID: 30442662.

Liu Y, Wang T, Ji YJ, Johnson K, Liu H, Johnson K, Bailey S, Suk Y, Lu YN, Liu M, Wang J. A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress. Genes Dev. 2018 Oct 26. PubMed PMID: 30366907.

Abraham R, Hauer D, McPherson RL, Utt A, Kirby IT, Cohen MS, Merits A, Leung AKL, Griffin DE. ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication. Proc Natl Acad Sci U S A. 2018 Oct 15. PubMed PMID: 30322911.

Chen F, Lu H, Chen P, Zhao X, Guan X, Liang Q, Zirkin B, Ye L, Chen H. Acute Effects of the Translocator Protein (TSPO) Drug Ligand FGIN-1-27 on Serum Testosterone and LH Levels in Male Sprague Dawley Rats. Biol Reprod. 2018 Oct 8. PubMed PMID: 30299464.

Weaver LN, Drummond-Barbosa D. Maintenance of Proper Germline Stem Cell Number Requires Adipocyte Collagen in Adult Drosophila Females. Genetics. 2018 Aug;209(4):1155-1166. PubMed PMID: 29884747.

Hawksworth DJ, Szafran AA, Jordan PW, Dobs AS, Herati AS. Infertility in Patients With Klinefelter Syndrome: Optimal Timing for Sperm and Testicular Tissue Cryopreservation. Rev Urol. 2018;20(2):56-62. PubMed PMID: 30288141.

Hwang G, Verver DE, Handel MA, Hamer G, Jordan PW. Depletion of SMC5/6 sensitizes male germ cells to DNA damage. Mol Biol Cell. 2018 Oct 3:mbcE18070459. PubMed PMID: 30281394.

Hurtado CG, Wan F, Housseau F, Sears CL. Roles for Interleukin 17 and Adaptive Immunity in Pathogenesis of Colorectal Cancer. Gastroenterology. 2018 Sep 12. PubMed PMID: 30218667.

Besold AN, Culbertson EM, Nam L, Hobbs RP, Boyko A, Maxwell CN, Chazin WJ, Marques AR, Culotta VC. Antimicrobial action of calprotectin that does not involve metal withholding. Metallomics. 2018 Sep 12. PubMed PMID: 30206620.

Musicki B, Karakus S, Akakpo W, Silva FH, Liu J, Chen H, Zirkin BR, Burnett AL. Testosterone replacement in transgenic sickle cell mice controls priapic activity and upregulates PDE5 expression and eNOS activity in the penis. Andrology. 2018 Jan;6(1):184-191. PubMed PMID: 29145710. 

Chung L, Thiele Orberg E, Geis AL, Chan JL, Fu K, DeStefano Shields CE, Dejea CM, Fathi P, Chen J, Finard BB, Tam AJ, McAllister F, Fan H, Wu X, Ganguly S, Lebid A, Metz P, Van Meerbeke SW, Huso DL, Wick EC, Pardoll DM, Wan F, Wu S, Sears CL, Housseau F. Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe. 2018 Feb 14;23(2):203-214.e5. PubMed PMID:
29398651. 

Abraham R, McPherson RL, Sreekumar E, Leung AKL, Griffin DE. Preparation of Recombinant Alphaviruses for Functional Studies of ADP-Ribosylation. Methods Mol Biol. 2018;1813:297-316. PubMed PMID: 30097877.
 
McPherson RL, Ong SE, Leung AKL. Quantitative Determination of MAR Hydrolase Residue Specificity In Vitro by Tandem Mass Spectrometry. Methods Mol Biol. 2018;1813:271-283. PubMed PMID: 30097875.
 
Leung AKL. PARPs. Curr Biol. 2017 Dec 4;27(23):R1256-R1258. PubMed PMID: 29207261.

Li Q, Weiland A, Chen X, Lan X, Han X, Durham F, Liu X, Wan J, Ziai WC, Hanley DF, Wang J. Ultrastructural Characteristics of Neuronal Death and White Matter Injury in Mouse Brain Tissues After Intracerebral Hemorrhage: Coexistence of Ferroptosis, Autophagy, and Necrosis. Front Neurol. 2018 Jul 17;9:581. PubMed PMID: 30065697. 

Lee CC, Matunis MJ. Resolving Chromatin Bridges With SIMs, SUMOs and PICH. Cell Cycle. 2016 Oct;15(19):2547-2548. Epub 2016 Jul 27. PubMed PMID: 27464337.

Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldívar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engström Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Köhler JR. Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. PLoS Pathog. 2018 Jul
30;14(7):e1007076. PubMed PMID: 30059535.

Evans JP, Robinson DN. Micropipette Aspiration of Oocytes to Assess Cortical Tension. Methods Mol Biol. 2018;1818:163-171. PubMed PMID: 29961265.
 
Nanjappa MK, Medrano TI, Prins GS, Chen H, Zirkin BR, Cooke PS. Transdifferentiation of adult rat stem Leydig cells into prostatic and uterine epithelium, but not epidermis. Andrology. 2017 Nov;5(6):1165-1173. PubMed PMID: 29073338.

Chen G, Bracamonte-Baran W, Diny NL, Hou X, Talor MV, Fu K, Liu Y, Davogustto G, Vasquez H, Taegtmeyer H, Frazier OH, Waisman A, Conway SJ, Wan F, Čiháková D. Sca-1(+) cardiac fibroblasts promote development of heart failure. Eur J Immunol. 2018 Jun 28. PubMed PMID:
29953616. 

Leung AKL, McPherson RL, Griffin DE. Macrodomain ADP-ribosylhydrolase and the 
pathogenesis of infectious diseases. PLoS Pathog. 2018 Mar 22;14(3):e1006864. PubMed PMID: 29566066.

Wellard SR, Hopkins J, Jordan PW. A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model. J Vis Exp. 2018 Feb 6;(132). PubMed PMID: 29443055.

Armstrong AR, Drummond-Barbosa D. Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers. Dev Biol. 2018 Aug 1;440(1):31-39. PubMed PMID: 29729259.
 
Hwang GH, Hopkins JL, Jordan PW. Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II. J Vis Exp. 2018 Feb 26;(132). PubMed PMID: 29553540.

Odeh HM, Coyaud E, Raught B, Matunis MJ. The SUMO-Specific Isopeptidase SENP2 is Targeted to Intracellular Membranes via a Predicted N-Terminal Amphipathic α-Helix. Mol Biol Cell. 2018 Jun 6. PubMed PMID: 29874116.

Kumar P, Chauhan V, Silva JRA, Lameira J, d'Andrea FB, Li SG, Ginell SL, Freundlich JS, Alves CN, Bailey S, Cohen KA, Lamichhane G. Mycobacterium abscessus l,d-Transpeptidases Are Susceptible to Inactivation by Carbapenems and Cephalosporins but Not Penicillins. Antimicrob Agents Chemother. 2017 Sep 22;61(10). PubMed PMID: 28760902.

Ji YJ, Ugolino J, Brady NR, Hamacher-Brady A, Wang J. Systemic deregulation of autophagy upon loss of ALS- and FTD-linked C9orf72. Autophagy. 2017 Jul 3;13(7):1254-1255. PubMed PMID: 28319438.

Fan J, Zirkin B, Papadopoulos V. Response to Letter to the Editor: "Dubious conclusions on TSPO function". Endocrinology. 2018 May 10. PubMed PMID: 29757373.

Miller PS, Evans JP. SELEX Screen for Zona Pellucida-Binding DNA Aptamers. Biol Reprod. 2018 May 22. PubMed PMID: 29790932.

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1666-1671.PubMed PMID: 28143925.

Armstrong AR, Drummond-Barbosa D. Insulin signaling acts in adult adipocytes via GSK-3β and independently of FOXO to control Drosophila female germline stem cell numbers. Dev Biol. 2018 May 2. PubMed PMID: 29729259.
 
Fu C, Rojas T, Chin AC, Cheng W, Bernstein IA, Albacarys LK, Wright WW, Snyder SH. Multiple aspects of male germ cell development and interactions with Sertoli cells require inositol hexakisphosphate kinase-1. Sci Rep. 2018 May 4;8(1):7039. PubMed PMID: 29728588.

Wang Y, Huang S, Wang Z, Chen F, Chen P, Zhao X, Lin H, Ge R, Zirkin B, Chen H. Long -term maintenance of luteinizing Hormone-Responsive testosterone formation by primary rat Leydig cells in vitro. Mol Cell Endocrinol. 2018 Apr 24. PubMed PMID: 29702242.

Banerjee PP, Banerjee S, Brown TR, Zirkin BR. Androgen action in prostate function and disease. Am J Clin Exp Urol. 2018 Apr 1;6(2):62-77. PubMed PMID: 29666834.

Lombardi PM, Matunis MJ, Wolberger C. RAP80, ubiquitin and SUMO in the DNA damage response. J Mol Med (Berl). 2017 Aug;95(8):799-807. PubMed PMID: 28681078.

Singh D, Wang Y, Mallon J, Yang O, Fei J, Poddar A, Ceylan D, Bailey S, Ha T. Mechanisms of improved specificity of engineered Cas9s revealed by single-molecule FRET analysis. Nat Struct Mol Biol. 2018 Apr;25(4):347-354. PubMed PMID: 29622787.

Nguyen DKH, Thombre R, Wang J. Autophagy as a Common Pathway in Amyotrophic Lateral Sclerosis. Neurosci Lett. 2018 Apr 4. PubMed PMID: 29626651.

Jacob JT, Coulombe PA, Kwan R, Omary MB. Types I and II Keratin Intermediate Filaments. Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4). PubMed PMID: 29610398.
 
 Daniels CM, Ong SE, Leung AKL. ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method. Methods Mol Biol. 2017;1608:79-93. PubMed PMID: 28695505.

Zirkin BR, Papadopoulos V. Leydig Cells: Formation, Function and Regulation. Biol Reprod. 2018 Mar 16. PubMed PMID: 29566165.
 
Leung AKL, McPherson RL, Griffin DE. Macrodomain ADP-ribosylhydrolase and the 
pathogenesis of infectious diseases. PLoS Pathog. 2018 Mar 22;14(3):e1006864. PubMed PMID: 29566066.
 
Jung EH, Meyers DJ, Bosch J, Casadevall A. Novel Antifungal Compounds Discovered in Medicines for Malaria Venture's Malaria Box. mSphere. 2018 Mar 14;3(2).  PubMed PMID: 29564402. 
 
Cao X, Zhou Y, Sun H, Xu M, Bi X, Zhao Z, Shen B, Wan F, Hong Z, Lan L, Luo L, Guo Z, Yin Z. EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790 M resistant mutation in lung cancer cells. Cancer Lett. 2018 Mar 7. PubMed PMID: 29524558.
 
Lee CC, Li B, Yu H, Matunis MJ. Sumoylation promotes optimal APC/C activation and timely anaphase. Elife. 2018 Mar 8;7. PubMed PMID: 29517484.

Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, Myong S, Kim JK, Shorter J, Ong SE, Leung AKL, Wang J. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell. 2018 Mar 1;69(5):787-801.e8.PubMed PMID: 29499134.

Fan J, Wang K, Zirkin B, Papadopoulos V. CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells. Endocrinology. 2018 Feb 1;159(2):1130-1146. PubMed PMID: 29300865.

Uzoma I, Hu J, Cox E, Xia S, Zhou J, Rho HS, Guzzo C, Paul C, Ajala O, Goodwin CR, Jeong J, Moore C, Zhang H, Meluh P, Blackshaw S, Matunis M, Qian J, Zhu H. Global Identification of SUMO Substrates Reveals Crosstalk between SUMOylation and Phosphorylation Promotes Cell Migration. Mol Cell Proteomics. 2018 Feb 8. PubMed PMID: 29438996.

Broxton CN, He B, Bruno VM, Culotta VC. A role for Candida albicans superoxide dismutase enzymes in glucose signaling. Biochem Biophys Res Commun. 2018 Jan 1. PubMed PMID: 29154829.

2017

Fan J, Wang K, Zirkin B, Papadopoulos V. CRISPR/CAS9-mediated Tspo gene mutations lead to reduced mitochondrial membrane potential and STEROID FORMation in MA-10 mouse tumor Leydig cells. Endocrinology. 2017 Dec 28. PubMed PMID: 29300865.

Reiter KH, Matunis MJ. Detection of SUMOylation in Plasmodium falciparum. Methods Mol Biol. 2016. PubMed PMID: 27631812.
 
Matunis MJ, Rodriguez MS. Concepts and Methodologies to Study Protein SUMOylation: An Overview. Methods Mol Biol. 2016. PubMed PMID: 27631794.

Robinett NG, Peterson RL, Culotta VC. Eukaryotic Cu-only superoxide dismutases (SODs): A new class of SOD enzymes and SOD-like protein domains. J Biol Chem. 2017 Dec 19. PubMed PMID: 29259135.
 
Rossi DCP, Gleason JE, Sanchez H, Schatzman SS, Culbertson EM, Johnson CJ, McNees CA, Coelho C, Nett JE, Andes DR, Cormack BP, Culotta VC. Candida albicans FRE8 encodes a member of the NADPH oxidase family that produces a burst of ROS during fungal morphogenesis. PLoS Pathog. 2017 Dec 1. PubMed PMID: 29194441.

Ables ET, Hwang GH, Finger DS, Hinnant TD, Drummond-Barbosa D. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. G3 (Bethesda). 2016 Aug PubMed PMID: 27226164.

Broxton CN, He B, Bruno VM, Culotta VC. A role for Candida albicans superoxide dismutase enzymes in glucose signaling. Biochem Biophys Res Commun. 2017 Nov 14. PubMed PMID: 29154829.
 
Musicki B, Karakus S, Akakpo W, Silva FH, Liu J, Chen H, Zirkin BR, Burnett AL. Testosterone replacement in transgenic sickle cell mice controls priapic activity and upregulates PDE5 expression and eNOS activity in the penis. Andrology. 2017 Nov 16. PubMed PMID: 29145710.

Besold AN, Gilston BA, Radin JN, Ramsoomair C, Culbertson EM, Li CX, Cormack BP, Chazin WJ, Kehl-Fie TE, Culotta VC. The role of calprotectin in withholding zinc and copper from Candida albicans. Infect Immun. 2017 Nov 13. PubMed PMID: 29133349.

Chen H, Wang Y, Ge R, Zirkin BR. Leydig cell stem cells: Identification, proliferation and differentiation. Mol Cell Endocrinol. 2017 Apr 15;445:65-73. PubMed PMID: 27743991.

Fu K, Sun X, Wier EM, Hodgson A, Hobbs RP, Wan F. Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice. Elife. 2016 Dec 20;5. pii: e21957. PubMed PMID: 27996939.

Singh D, Paduch DA, Schlegel PN, Orwig KE, Mielnik A, Bolyakov A, Wright WW. The production of glial cell line-derived neurotrophic factor by human sertoli cells is substantially reduced in sertoli cell-only testes. Hum Reprod. 2017 May 1;32(5):1108-1117. PubMed PMID: 28369535.

Hwang G, Sun F, O'Brien M, Eppig JJ, Handel MA, Jordan PW. SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 2017 May 1;144(9):1648-1660. PubMed PMID: 28302748. 

Kumar P, Chauhan V, Silva JRA, Lameira J, d'Andrea F, Li S, Ginell SL, Freundlich JS, Alves CN, Bailey S, Cohen KA, Lamichhane G. Mycobacterium abscessus L,D-transpeptidases are susceptible to inactivation by carbapenems and cephalosporins but not penicillins. Antimicrob Agents Chemother. 2017 Jul 31. PubMed PMID: 28760902.

Johnson K, Bailey S. Microbiology: The case of the mysterious messenger. Nature. 2017 Aug 2. PubMed PMID: 28783729. 
 
Chen H, Wang Y, Ge R, Zirkin BR. Corrigendum to "Leydig cell stem cells: Identification, proliferation and differentiation" [Mol. Cell. Endocrinol. XXX (2016) 1-9]. Mol Cell Endocrinol. 2017 Oct 15;454:166. PubMed PMID: 28780938.
 
Chen H, Jin S, Huang S, Folmer J, Liu J, Ge R, Zirkin BR. Corrigendum to "Transplantation of alginate-encapsulated seminiferous tubules and interstitial tissue into adult rats: Leydig stem cell differentiation in vivo?" [Mol. Cell. Endocrinol. 436 (2016) 250-258]. Mol Cell Endocrinol. 2017 Oct 15;454:165. PubMed PMID: 28780937.

Fu K, Wan F. Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells. Cell Chem Biol. 2017 Jul 20;24(7):777-779. PubMed PMID: 28732196.

Fan AC, Leung AK. RNA Granules and Diseases: A Case Study of Stress Granules in ALS and FTLD. Adv Exp Med Biol. 2016;907:263-96. PubMed PMID: 27256390.

Langseth AJ, Kim J, Ugolino JE, Shah Y, Hwang HY, Wang J, Bergles DE, Brown SP. Cell-type specific differences in promoter activity of the ALS-linked C9orf72 mouse ortholog. Sci Rep. 2017 Jul 18;7(1):5685. PubMed PMID: 28720882.
 
Broxton CN, Culotta VC. An Adaptation to Low Copper in Candida albicans Involving SOD Enzymes and the Alternative Oxidase. PLoS One. 2016 Dec 29;11(12):e0168400. PubMed PMID: 28033429.

Matsuoka S, Armstrong AR, Sampson LL, Laws KM, Drummond-Barbosa D. Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster. Genetics. 2017 Jun;206(2):953-971. PubMed PMID: 28396508.
 
Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel M, Ehlting C, Bode JG, Müller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin H, Sánchez A, Dooley S, Ten Dijke P. BMP-9 interferes with liver regeneration and promotes liver fibrosis. Gut. 2017 May;66(5):939-954. PubMed PMID: 28336518.

Daniels CM, Ong SE, Leung AKL. ADP-Ribosylated Peptide Enrichment and Site Identification: The Phosphodiesterase-Based Method. Methods Mol Biol. 2017;1608:79-93. PubMed PMID: 28695505. 

Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS. Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? Bioessays. 2017 Jul 7. PubMed PMID: 28685843.

Lombardi PM, Matunis MJ, Wolberger C. RAP80, ubiquitin and SUMO in the DNA damage response. J Mol Med (Berl). 2017 Jul 5. PubMed PMID: 28681078.

Sun X, Fu K, Hodgson A, Wier EM, Wen MG, Kamenyeva O, Xia X, Koo LY, Wan F. Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation. PLoS Biol. 2016 Sep 16;14(9):e1002543. PubMed PMID: 27635653.

Papadopoulos V, Fan J, Zirkin B. Translocator protein (18 kDa): an update on its function in steroidogenesis. J Neuroendocrinol. 2017 Jul 1. PubMed PMID: 28667781.

Palazzo L, anielsD CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I. ENPP1 processes protein ADP-ribosylation in vitro. FEBS J. 2016 Sep;283(18):3371-88. PubMed PMID: 27406238.

Laws KM, Drummond-Barbosa D. Control of Germline Stem Cell Lineages by Diet and Physiology. Results Probl Cell Differ. 2017;59:67-99. PubMed PMID: 28247046.

Hobbs RP, Jacob JT, Coulombe PA. Keratins Are Going Nuclear. Dev Cell. 2016 Aug 8;38(3):227-33. PubMed PMID: 27505414.
 
Vom Steeg LG, Vermillion MS, Hall OJ, Alam O, McFarland R, Chen H, Zirkin B, Klein SL. Age and testosterone mediate influenza pathogenesis in male mice. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1234-L1244. PubMed PMID: 27815260.

Fischer JW, Leung AK. CircRNAs: a regulator of cellular stress. Crit Rev Biochem Mol Biol. 2017 Apr;52(2):220-233. PubMed PMID: 28095716.
 
Laws KM, Drummond-Barbosa D. AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis. Dev Biol. 2016 Dec 1;420(1):90-99. PubMed PMID: 27729213.

Newman HA, Meluh PB, Lu J, Vidal J, Carson C, Lagesse E, Gray JJ, Boeke JD, Matunis MJ. A high throughput mutagenic analysis of yeast sumo structure and function. PLoS Genet. 2017 Feb 6;13(2):e1006612. PubMed PMID: 28166236.

Peterson RL, Galaleldeen A, Villarreal J, Taylor AB, Cabelli DE, Hart PJ, Culotta VC. The Phylogeny and Active Site Design of Eukaryotic Copper-only Superoxide Dismutases. J Biol Chem. 2016 Sep 30;291(40):20911-20923. PubMed PMID: 27535222.

Ugolino J, Ji YJ, Conchina K, Chu J, Nirujogi RS, Pandey A, Brady NR, Hamacher-Brady A, Wang J. Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling. PLoS Genet. 2016 Nov 22;12(11):e1006443. PubMed PMID: 27875531.

Zhong Y, Wang J, Henderson MJ, Yang P, Hagen BM, Siddique T, Vogel BE, Deng HX, Fang S. Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus. Elife. 2017 May 2;6. PubMed PMID: 28463106.

Ables ET, Drummond-Barbosa D. Steroid Hormones and the Physiological Regulation of Tissue-Resident Stem Cells: Lessons from the Drosophila Ovary. Curr Stem Cell Rep. 2017 Mar;3(1):9-18. PubMed PMID: 28458991.

Evans JP, Leppert PC. "Feeling the force" in reproduction: Mechanotransduction in reproductive processes. Connect Tissue Res. 2016 May;57(3):236-44. PubMed PMID: 27070825.

Hsu HJ, Drummond-Barbosa D. A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines. Gene Expr Patterns. 2017 Jan;23-24:13-21. PubMed PMID: 28093350.

Coulombe PA. The Molecular Revolution in Cutaneous Biology: Keratin Genes and their Associated Disease: Diversity, Opportunities, and Challenges. J Invest Dermatol. 2017 May;137(5):e67-e71. PubMed PMID: 28411849.

Singh D, Paduch DA, Schlegel PN, Orwig KE, Mielnik A, Bolyakov A, Wright WW. The production of glial cell line-derived neurotrophic factor by human sertoli cells is substantially reduced in sertoli cell-only testes. Hum Reprod. 2017 Mar 23:1-10. PubMed PMID: 28369535.

Ji Y, Ugolino J, Brady NR, Hamacher-Brady A, Wang J. Systemic Deregulation of Autophagy Upon Loss of ALS- and FTD-linked C9orf72. Autophagy. 2017 Mar 20:0. PubMed PMID: 28319438.

Leung AK. SERious Surprises for ADP-Ribosylation Specificity: HPF1 Switches PARP1 Specificity to Ser Residues. Mol Cell. 2017 Mar 2;65(5):777-778. PubMed PMID: 28257697.

Das S, Kohr M, Dunkerly-Eyring B, Lee DI, Bedja D, Kent OA, Leung AK, Henao-Mejia J, Flavell RA, Steenbergen C. Divergent Effects of miR-181 Family Members on Myocardial Function Through Protective Cytosolic and Detrimental Mitochondrial microRNA Targets. J Am Heart Assoc. 2017 Feb 27;6(3). PubMed PMID: 28242633.

Verver DE, Hwang GHJordan PW, Hamer G. Resolving complex chromosome structures during meiosis: versatile deployment of Smc5/6. Chromosoma. 2016 Mar;125(1):15-27. PubMed PMID: 25947290.

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK. ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence. Proc Natl Acad Sci U S A. 2017 Jan 31. pii: 201621485. PubMed PMID: 28143925.

Hwang HY, Wang J. Effect of mutation mechanisms on variant composition and distribution in Caenorhabditis elegans. PLoS Comput Biol. 2017 Jan 30;13(1):e1005369. PubMed PMID: 28135268.

Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic Acids Res. 2017 Jan 18. pii: gkx035. PubMed PMID: 28100694.

Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S. Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res. 2017 Jan 3. PubMed PMID: 28050734.

2016

Broxton CN, Culotta VC. An Adaptation to Low Copper in Candida albicans Involving SOD Enzymes and the Alternative Oxidase. PLoS One. 2016 Dec 29;11(12):e0168400. PubMed PMID: 28033429.

Yang Y, Li Z, Wu X, Chen H, Xu W, Xiang Q, Zhang Q, Chen J, Ge RS, Su Z, Huang Y. Direct Reprogramming of Mouse Fibroblasts toward Leydig-like Cells by Defined Factors. Stem Cell Reports. 2016 Dec 20. pii: S2213-6711(16)30272-7. PubMed PMID: 28017657.

Fu K, Sun X, Wier EM, Hodgson A, Hobbs RP, Wan F. Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice. Elife. 2016 Dec 20;5. pii: e21957. PubMed PMID: 27996939.

Besold AN, Culbertson EM, Culotta VC. The Yin and Yang of copper during infection. J Biol Inorg Chem. 2016 Apr;21(2):137-44. PubMed PMID: 26790881.

Kerns ML, Guss L, Fahey J, Cohen B, Hakim JM, Sung S, Lu RG, Coulombe PA. Randomized, split-body, single-blinded clinical trial of topical broccoli sprout extract: Assessing the feasibility of its use in keratin-based disorders. J Am Acad Dermatol. 2016 Nov 23. PubMed PMID: 27889290.

Ramachandran A, Bailey S. Memory Upgrade: Insights into Primed Adaptation by CRISPR-Cas Immune Systems. Mol Cell. 2016 Nov 17;64(4):641-642. PubMed PMID: 27863223.

Robison P, Sussan TE, Chen H, Biswal S, Schneider MF, Hernández-Ochoa EO. Impaired Calcium Signaling in Muscle Fibers from Intercostal and Foot Skeletal Muscle in a Cigarette Smoke-Induced Mouse Model of COPD. Muscle Nerve. 2016 Nov 11. PubMed PMID: 27862020.

McLaughlin D, Coey CT, Yang WC, Drohat AC, Matunis MJ. Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo. J Biol Chem.2016 Apr 22;291(17):9014-24. PubMed PMID: 26917720.

Daniels CM, Thirawatananond P, Ong SE, Gabelli SB, Leung AK. Nudix hydrolases degrade protein-conjugated ADP-ribose. Sci Rep. 2015 Dec 16;5:18271.PubMed PMID: 26669448.

Hobbs RP, Batazzi AS, Han MC, Coulombe PA. Loss of Keratin 17 induces tissue-specific cytokine polarization and cellular differentiation in HPV16-driven cervical tumorigenesis in vivo. Oncogene. 2016 Oct 27;35(43):5653-5662. PubMed PMID: 27065324.

Hodgson A, Wan F. Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: global and selective inhibition. Mol Microbiol. 2016 Feb;99(3):439-52. PubMed PMID: 26449378. 

Chen H, Wang Y, Ge R, Zirkin BR. Leydig cell stem cells: Identification, proliferation and differentiation. Mol Cell Endocrinol. 2016 Oct 12. PubMed PMID: 27743991.

Wang F, Zieman A, Coulombe PA. Skin Keratins. Methods Enzymol. 2016;568:303-50. PubMed PMID: 26795476.

Lee CC, Matunis MJ. Resolving Chromatin Bridges With SIMs, SUMOs and PICH. Cell Cycle. 2016 Oct;15(19):2547-2548. PubMed PMID: 27464337. 

Kuznedelov K, Mekler V, Lemak S, Tokmina-Lukaszewska M, Datsenko KA, Jain I, Savitskaya E, Mallon J, Shmakov S, Bothner B, Bailey S, Yakunin AF, Severinov K, Semenova E. Altered stoichiometry Escherichia coli Cascade complexes with shortened CRISPR RNA spacers are capable of interference and primed adaptation.Nucleic Acids Res. 2016 Oct 13. PubMed PMID: 27738137.

Coulombe PA. Discovery of keratin function and role in genetic diseases: the year that 1991 was. Mol Biol Cell. 2016 Sep 15;27(18):2807-10. PubMed PMID: 27634744.

Reiter KH, Matunis MJ. Detection of SUMOylation in Plasmodium falciparum. Methods Mol Biol. 2016;1475:283-290. PubMed PMID: 27631812.

Matunis MJ, Rodriguez MS. Concepts and Methodologies to Study Protein SUMOylation: An Overview. Methods Mol Biol. 2016;1475:3-22. PubMed PMID: 27631794.

Mallon J, Bailey S. A molecular arms race: new insights into anti-CRISPR mechanisms. Nat Struct Mol Biol. 2016 Sep 6;23(9):765-6. PubMed PMID: 27605202.

Chen H, Guo J, Ge R, Lian Q, Papadopoulos V, Zirkin BR. Steroidogenic fate of the Leydig cells that repopulate the testes of young and aged Brown Norway rats after elimination of the preexisting Leydig cells. Exp Gerontol. 2015 Dec;72:8-15. Epub 2015 Sep 1. PubMed PMID: 26335619.

Chen H, Jin S, Huang S, Folmer J, Liu J, Ge R, Zirkin BR. Transplantation of alginate-encapsulated seminiferous tubules and interstitial tissue into adult rats: Leydig stem cell differentiation in vivo? Mol Cell Endocrinol. 2016 Aug 30. pii: S0303-7207(16)30353-7. PubMed PMID: 27591121.

Vivelo CA, Wat R, Agrawal C, Tee HY, Leung AK. ADPriboDB: The database of ADP-ribosylated proteins. Nucleic Acids Res. 2016 Aug 9. PubMed PMID: 27507885.

Li X, Wang Z, Jiang Z, Guo J, Zhang Y, Li C, Chung J, Folmer J, Liu J, Lian Q, Ge R, Zirkin BR, Chen H. Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2666-71. Epub 2016 Feb 29. PubMed PMID: 26929346. 

Fu K, Sun X, Wier EM, Hodgson A, Liu Y, Sears CL, Wan F. Sam68/KHDRBS1 is critical for colon tumorigenesis by regulating genotoxic stress-induced NF-κB activation. Elife. 2016 Jul 25;5. pii: e15018. doi: 10.7554/eLife.15018. PubMed PMID: 27458801.

an Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L,Baker M, Baker S, Ben Mamoun C, Bhatia S, Bickle Q, Bounaadja L, Bowling T, Bosch J, Boucher LE, Boyom FF, Brea J, Brennan M, Burton A, Caffrey CR, Camarda G, Carrasquilla M, Carter D, Belen Cassera M, Chih-Chien Cheng K, Chindaudomsate W, Chubb A, Colon BL, Colón-López DD, Corbett Y, Crowther GJ, Cowan N, D'Alessandro S, Le Dang N, Delves M, DeRisi JL, Du AY, Duffy S, Abd El-Salam El-Sayed S, Ferdig MT, Fernández Robledo JA, Fidock DA, Florent I, Fokou PV, Galstian A,amo FJ, Gokool S, Gold B, Golub T, Goldgof GM, Guha R, Guiguemde WA, Gural N, Guy RK, Hansen MA, Hanson KK, Hemphill A, Hooft van Huijsduijnen R, Horii T, Horrocks P, Hughes TB, Huston C, Igarashi I, Ingram-Sieber K, Itoe MA, Jadhav A, Naranuntarat Jensen A, Jensen LT, Jiang RH, Kaiser A, Keiser J, Ketas T, Kicka S, Kim S, Kirk K, Kumar VP, Kyle DE, Lafuente MJ, Landfear S, Lee N, Lee S, Lehane AM, Li F, Little D, Liu L, Llinás M, Loza MI, Lubar A, Lucantoni L, Lucet I, Maes L, Mancama D, Mansour NR, March S, McGowan S, Medina Vera I, Meister S, Mercer L, Mestres J, Mfopa AN, Misra RN, Moon S, Moore JP, Morais Rodrigues da Costa F, Müller J, Muriana A, Nakazawa Hewitt S, Nare B, Nathan C, Narraidoo N, Nawaratna
S, Ojo KK, Ortiz D, Panic G, Papadatos G, Parapini S, Patra K, Pham N, Prats S, Plouffe DM, Poulsen SA, Pradhan A, Quevedo C, Quinn RJ, Rice CA, Abdo Rizk M, Ruecker A, St Onge R, Salgado Ferreira R, Samra J, Robinett NG, Schlecht U, Schmitt M, Silva Villela F, Silvestrini F, Sinden R, Smith DA, Soldati T, Spitzmüller A, Stamm SM, Sullivan DJ, Sullivan W, Suresh S, Suzuki BM, Suzuki Y, Swamidass SJ, Taramelli D, Tchokouaha LR, Theron A, Thomas D, Tonissen KF, Townson S, Tripathi AK, Trofimov V, Udenze KO, Ullah I, Vallieres C, Vigil E, Vinetz JM, Voong Vinh P, Vu H, Watanabe NA, Weatherby K, White PM, Wilks AF, Winzeler EA, Wojcik E, Wree M, Wu W, Yokoyama N, Zollo PH, Abla N, Blasco B, Burrows J, Laleu B, Leroy D, Spangenberg T, Wells T, Willis PA. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS Pathog. 2016 Jul 28;12(7):e1005763. PubMed PMID: 27467575.

Fu C, Begum K, Jordan PW, He Y, Overbeek PA. Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice. PLoS One. 2016 Aug 3;11(8):e0159800. PubMed PMID: 27486799.

Hodgson A, Wier EM, Fu K, Sun X, Wan F. Ultrasound imaging of splenomegaly as a proxy to monitor colon tumor development in Apc(min716/+) mice. Cancer Med. 2016 Aug 3. PubMed PMID: 27485505.

Palazzo L, Daniels CM, Nettleship JE, Rahman N, McPherson RL, Ong SE, Kato K, Nureki O, Leung AK, Ahel I. ENPP1 processes protein ADP-ribosylation in vitro. FEBS J. 2016 Jul 12. PubMed PMID: 27406238.

Reiter KH, Ramachandran A, Xia X, Boucher LE, Bosch J, Matunis MJ. Characterization and Structural Insights into Selective E1-E2 Interactions in the Human and Plasmodium falciparum SUMO Conjugation Systems. J Biol Chem. 2016 Feb 19;291(8):3860-70. PubMed PMID:
26697886.

McPherson RL, Leung AK. ADPr-ChAP: Mapping ADP-Ribosylation onto the Genome. Mol Cell. 2016 Feb 4;61(3):327-8. PubMed PMID: 26849191.

Hwang T, Park CK, Leung AK, Gao Y, Hyde TM, Kleinman JE, Rajpurohit A, Tao R, Shin JH, Weinberger DR. Dynamic regulation of RNA editing in human brain development and disease. Nat Neurosci. 2016 Jun 27. PubMed PMID: 27348216.

Leung AK. The Whereabouts of microRNA Actions: Cytoplasm and Beyond. Trends Cell Biol. 2015 Oct;25(10):601-10. PubMed PMID: 26410406. 

Luo H, Shenoy AK, Li X, Jin Y, Jin L, Cai Q, Tang M, Liu Y, Chen H, Reisman D, Wu L, Seto E, Qiu Y, Dou Y, Casero RA Jr, Lu J. MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition. Cell Rep. 2016 Jun 7. PubMed PMID: 27292636.

Laws KM, Drummond-Barbosa D. Genetic Mosaic Analysis of Stem Cell Lineages in the Drosophila Ovary. Methods Mol Biol. 2015;1328:57-72. PubMed PMID: 26324429.

Gao L, Li D, Ma K, Zhang W, Xu T, Fu C, Jing C, Jia X, Wu S, Sun X, Dong M, Deng M, Chen Y, Zhu W, Peng J, Wan F, Zhou Y, Zon LI, Pan W. TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive Hematopoiesis. PLoS Genet. 2015 Jul 1;11(7):e1005346. eCollection 2015 Jul. PubMed PMID: 26131719/ 

Aghazadeh Y, Zirkin BR, Papadopoulos V. Pharmacological regulation of the cholesterol transport machinery in steroidogenic cells of the testis. Vitam Horm. 2015;98:189-227. Epub 2015 Feb 14. Review. PubMed PMID: 25817870.

Traore K, Martinez-Arguelles DB, Papadopoulos V, Chen H, Zirkin BR. Repeated Exposures of the Male Sprague Dawley Rat Reproductive Tract to Environmental Toxicants: Do Earlier Exposures to Di-(2-Ethylhexyl) Phthalate (DEHP) Alter the Effects of Later Exposures? Reprod Toxicol. 2016 Mar 31. pii: S0890-6238(16)30047-8. PubMed PMID: 27040317.

Musicki B, Zhang Y, Chen H, Brown TR, Zirkin BR, Burnett AL. Mechanism of testosterone deficiency in the transgenic sickle cell mouse. PLoS One. 2015 May 29;10(5):e0128694. PubMed PMID: 26023917. 

Hayes RP, Xiao Y, Ding F, van Erp PB, Rajashankar K, Bailey S, Wiedenheft B, Ke A. Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature. 2016 Feb 25;530(7591):499-503. Epub 2016 Feb 10. PubMed PMID: 26863189.

Chen H, Bailey S. Structural biology. Cas9, poised for DNA cleavage. Science. 2016 Feb 19;351(6275):811-2. PubMed PMID: 26912877.

Rice SL, Boucher LE, Schlessman JL, Preimesberger MR, Bosch J, Lecomte JT. Structure of Chlamydomonas reinhardtii THB1, a group 1 truncated hemoglobin with a rare histidine-lysine heme ligation. Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):718-25. Epub 2015 May 20. PubMed PMID: 26057801.

McGinnis LA, Lee HJ, Robinson DN, Evans JP. MAPK3/1 (ERK1/2) and Myosin Light Chain Kinase in Mammalian Eggs Affect Myosin-II Function and Regulate the Metaphase II State in a Calcium- and Zinc-Dependent Manner. Biol Reprod. 2015 Jun;92(6):146. Epub 2015 Apr 22. PubMed PMID: 25904014.

Wier EM, Fu K, Hodgson A, Sun X, Wan F. Caspase-3 cleaved p65 fragment dampens
NF-κB-mediated anti-apoptotic transcription by interfering with the p65/RPS3 interaction. FEBS Lett. 2015 Nov 30;589(23):3581-7. Epub 2015 Oct 23. PubMed PMID: 26526615.

Matthews LM, Evans JP. α-endosulfine (ENSA) regulates exit from prophase I arrest in mouse oocytes. Cell Cycle. 2014;13(10):1639-49. Epub 2014 Mar 25. PubMed PMID: 24675883. 

Mackenzie AC, Kyle DD, McGinnis LA, Lee HJ, Aldana N, Robinson DN, Evans JP. Cortical mechanics and myosin-II abnormalities associated with post-ovulatory aging: Implications for functional defects in aged eggs. Mol Hum Reprod. 2016 Feb 26. pii: gaw019. [Epub ahead of print] PubMed PMID: 26921397.

Pryzhkova MV, Jordan PW. Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression. J Cell Sci. 2016 Feb 26. pii: jcs.179036. [Epub ahead of print] PubMed PMID: 26919979.

Chen H, Bailey S. Cas9, poised for DNA cleavage. Science. 2016 Feb 19;351(6275):811-2. PubMed PMID: 26912877.

Zuckerman DM, Boucher LE, Xie K, Engelhardt H, Bosch J, Hoiczyk E. The bactofilin cytoskeleton protein BacM of Myxococcus xanthus forms an extended β-sheet structure likely mediated by hydrophobic interactions. PLoS One. 2015 Mar 24;10(3):e0121074. PubMed
PMID: 25803609.

Chen H, Jin S, Guo J, Kombairaju P, Biswal S, Zirkin BR. Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells. Mol Cell Endocrinol. 2015 Jul 5;409:113-20. PubMed PMID: 25818884.

Hayes RP, Xiao Y, Ding F, van Erp PB, Rajashankar K, Bailey S, Wiedenheft B, Ke A. Structural basis for promiscuous PAM recognition in type I-E Cascade from E. coli. Nature. 2016 Feb 10. PubMed PMID: 26863189.

Papadopoulos V, Aghazadeh Y, Fan J, Campioli E, Zirkin B, Midzak A. Translocator protein-mediated pharmacology of cholesterol transport and steroidogenesis. Mol Cell Endocrinol. 2015 Jun 15;408:90-8. PubMed PMID: 25818881. 

Estrella MA, Kuo FT, Bailey S. RNA-activated DNA cleavage by the Type III-B
CRISPR-Cas effector complex. Genes Dev. 2016 Feb 4. PubMed PMID: 26848046.

Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG. Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. J Neurosci. 2015 Oct 21;35(42):14286-306. PubMed PMID: 26490867. 

Boucher LE, Bosch J. The apicomplexan glideosome and adhesins - Structures and function. J Struct Biol. 2015 May;190(2):93-114. PubMed PMID: 25764948.

Christianson MS, Gerolstein AL, Lee HJ, Monseur BC, Robinson DN, Evans JP. Effects of inhibition of ubiquitin C-terminal hydrolase L1 (UCH-L1) on sperm incorporation and cortical tension in mouse eggs. Mol Reprod Dev. 2016 Jan 19. PubMed PMID: 26781791.

Hodgson A, Wier EM, Fu K, Sun X, Yu H, Zheng W, Sham HP, Johnson K, Bailey S, Vallance BA, Wan F. Metalloprotease NleC suppresses host NF-κB/inflammatory responses by cleaving p65 and interfering with the p65/RPS3 interaction. PLoS Pathog. 2015 Mar 10;11(3):e1004705. PubMed PMID: 25756944.

van Erp PB, Jackson RN, Carter J, Golden SM, Bailey S, Wiedenheft B. Mechanism of CRISPR-RNA guided recognition of DNA targets in Escherichia coli. Nucleic Acids Res. 2015 Sep 30;43(17):8381-91. PubMed PMID: 26243775.

Hain AU, Miller AS, Levitskaya J, Bosch J. Virtual Screening and Experimental Validation Identify Novel Inhibitors of the Plasmodium falciparum Atg8-Atg3 Protein-Protein Interaction. ChemMedChem. 2016 Jan 8. PubMed PMID: 26748931.

Broxton CNCulotta VC. SOD Enzymes and Microbial Pathogens: Surviving the Oxidative Storm of Infection. PLoS Pathog. 2016 Jan 7;12(1):e1005295. PubMed PMID: 26742105.

2015

Feng X, Coulombe PA. Complementary roles of specific cysteines in keratin 14
toward the assembly, organization, and dynamics of intermediate filaments in skin
keratinocytes. J Biol Chem. 2015 Sep 11;290(37):22507-19. PubMed PMID: 26216883. 

Ando Y, Leung AK. Methods for studying microRNA functions during stress. Methods Mol Biol. 2015;1292:115-28. PubMed PMID: 25804752.

Wang J, Haeusler AR, Simko EA. Emerging role of RNA•DNA hybrids in C9orf72-linked neurodegeneration. Cell Cycle. 2015;14(4):526-32. PubMed PMID: 25590632. 

Hodgson AWan F. Interference with NF-κB signaling pathway by pathogen-encoded proteases: global and selective inhibition. Mol Microbiol. 2015 Oct 9. PubMed PMID: 26449378.

Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJWang J, Sattler R, Lloyd TE, Rothstein JD. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 2015 Sep 3;525(7567):56-61. PubMed PMID: 26308891.

Midzak A, Zirkin B, Papadopoulos V. Translocator protein: pharmacology and steroidogenesis. Biochem Soc Trans. 2015 Aug 1;43(4):572-578. PubMed PMID: 26551695.

Nayak S, Bryant FR. Kinetics of the ATP and dATP-mediated formation of a functionally-active RecA-ssDNA complex. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1257-61. PubMed PMID: 26100204.

Smith RC, Colón-López DD, Bosch J. Immunization against a merozoite sheddase promotes multiple invasion of red blood cells and attenuates Plasmodium infection in mice. Malar J. 2014 Aug 12;13:313. PubMed PMID: 25115675.

Weaver LN, Drummond-Barbosa D. Gut healing: haemocytes aid via Sax and Tkv jazzes it down. Nat Cell Biol. 2015 Jun;17(6):707-9. PubMed PMID: 26022916.

Hobbs RP, DePianto DJ, Jacob JT, Han MC, Chung BM, Batazzi AS, Poll BG, Guo Y, Han J, Ong S, Zheng W, Taube JM, Čiháková D, Wan F, Coulombe PA. Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes. Nat Genet. 2015 Aug;47(8):933-8.PubMed PMID: 26168014.

Çelik H, Hong SH, Colón-López DD, Han J, Kont YS, Minas TZ, Swift M, Paige M, Glasgow E, Toretsky JA, Bosch J, Üren A.Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box.Mol Cancer Ther. 2015 Nov;14(11):2497-507. Epub 2015 Sep 10.

Nemetski SM, Cardozo TJ, Bosch G, Weltzer R, O'Malley K, Ejigiri I, Kumar KA, Buscaglia CA, Nussenzweig V, Sinnis P, Levitskaya J, Bosch J. Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex. Malar J. 2015 Aug 20;14(1):324. PubMed PMID: 26289816

Li CX, Gleason JE, Zhang SX, Bruno VM, Cormack BP, Culotta VC. Candida albicans adapts to host copper during infection by swapping metal cofactors for superoxide dismutase. Proc Natl Acad Sci U S A. 2015 Sep 8. PubMed PMID: 26351691

Daniels CM, Ong SE, Leung AK. The Promise of Proteomics for the Study of ADP-Ribosylation. Mol Cell. 2015 Jun 18;58(6):911-24. PubMed PMID: 26091340.

Vivelo CA, Leung AK. Proteomics approaches to identify mono-(ADP-ribosyl)ated and poly(ADP-ribosyl)ated proteins. Proteomics. 2015 Jan;15(2-3):203-17. PubMed PMID: 25263235. 

Ouyang P, Gottlieb SH, Culotta VL, Navas-Acien A. EDTA Chelation Therapy to Reduce Cardiovascular Events in Persons with Diabetes. Curr Cardiol Rep. 2015 Nov;17(11):96. PubMed PMID: 26364188.

Baron JA, Chen JS, Culotta VC. Cu/Zn superoxide dismutase and the proton ATPase Pma1p of Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2015 May 6. PubMed PMID: 25956063.

Feng XCoulombe PA. A role for disulfide bonding in keratin intermediate filament organization and dynamics in skin keratinocytes. J Cell Biol. 2015 Apr 13;209(1):59-72. PubMed PMID: 25869667.

Periz G, Lu J, Zhang T, Kankel MW, Jablonski AM, Kalb R, McCampbell A, Wang J. Regulation of protein quality control by UBE4B and LSD1 through p53-mediated transcription. PLoS Biol. 2015 Apr 2;13. PubMed PMID: 25837623.

Graham MKBrown TR, Miller PS. Targeting the human androgen receptor gene with platinated triplex-forming oligonucleotides. Biochemistry. 2015 Apr 7;54(13):2270-82. PubMed PMID:25768916.

Chung BM, Arutyunov A, Ilagan E, Yao N, Wills-Karp M, Coulombe PA. Regulation of C-X-C chemokine gene expression by keratin 17 and hnRNP K in skin tumor keratinocytes. J Cell Biol. 2015 Mar 2;208(5):613-27. PubMed PMID: 25713416.

Beattie MC, Adekola L, Papadopoulos V, Chen H, Zirkin BR. Leydig cell aging and hypogonadism. Exp Gerontol. 2015 Feb 18.PubMed PMID: 25700847.

Salehi S, Adeshina I, Chen H, Zirkin BR, Hussain MA, Wondisford F, Wolfe A, Radovick S. Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells. Endocrinology. 2015 Apr;156(4):1514-22.PubMed PMID: 25635620.

Ables ET, Bois KE, Garcia CA, Drummond-Barbosa D. Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila. Dev Biol. 2015 Apr 1;400(1):33-42.PubMed PMID: 25624267.

Laws KM, Sampson LL, Drummond-Barbosa D. Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance. Dev Biol. 2015 Mar 15;399(2):226-36.PubMed PMID: 25576925.

2014

Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC,Malik AA, Wanyiri JW, Goh KL, Thevambiga I, Fu K, Wan F, Llosa N, Housseau F,Romans K, Wu X, McAllister FM, Wu S, Vogelstein B, Kinzler KW, Pardoll DM, Sears CL. Microbiota organization is a distinct feature of proximal colorectal cancers.Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18321-6. PubMed PMID: 25489084.

Armstrong AR, Laws KM, Drummond-Barbosa D. Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Development. 2014 Dec;141(23):4479-88. PubMed PMID: 25359724.

Zhang T, Baldie G, Periz G, Wang J. RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. PLoS Genet. 2014 Oct 16;10(10):e1004693. PubMed PMID: 25329970.

Boucher LE, Bosch J. Structure of Toxoplasma gondii fructose-1,6-bisphosphate aldolase. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1186-92.PubMed PMID: 25195889.

Richardson RJ, Hammond NL, Coulombe PA, Saloranta C, Nousiainen HO, Salonen R,
Berry A, Hanley N, Headon D, Karikoski R, Dixon MJ. Periderm prevents pathological epithelial adhesions during embryogenesis. J Clin Invest. 2014 Sep 2;124(9):3891-900. PubMed PMID:25133425.

Mulepati S, Héroux A, Bailey S. Crystal structure of a CRISPR RNA-guided
surveillance complex bound to a ssDNA target. Science. 2014 Aug 14. PubMed PMID: 25123481.

Hopkins J, Hwang G, Jacob J, Sapp N, Bedigian R, Oka K, Overbeek P, Murray S, Jordan PW. Meiosis-specific cohesin component, Stag3 is essential for maintaining centromere chromatid cohesion, and required for DNA repair and synapsis between homologous chromosomes. PLoS Genet. 2014 Jul 3;10(7):e1004413. PubMed PMID: 24992337.

Daniels CM, Ong SE, Leung AK. Phosphoproteomic approach to characterize protein mono- and poly(ADP-ribosyl)ation sites from cells. J Proteome Res. 2014 Aug 1;13(8):3510-22. PubMed PMID: 24920161.

Leung AK. Poly(ADP-ribose): an organizer of cellular architecture. J Cell Biol. 2014 Jun 9;205(5):613-9. PubMed PMID: 24914234;

Alvarado DM, Coulombe PA. Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice. J Biol Chem. 2014 Jul 11;289(28):19435-47. PubMed PMID: 24867950.

Verver DE, Langedijk NS, Jordan PW, Repping S, Hamer G. The SMC5/6 complex is involved in crucial processes during human spermatogenesis. Biol Reprod. 2014 Jul;91(1):22. PubMed PMID: 24855106.

Hain AU, Bartee D, Sanders NG, Miller AS, Sullivan DJ, Levitskaya J, Meyers CF, Bosch J. Identification of an Atg8-Atg3 protein-protein interaction inhibitor from the medicines for Malaria Venture Malaria Box active in blood and liver stage Plasmodium falciparum parasites. J Med Chem. 2014 Jun 12;57(11):4521-31. PubMed PMID: 24786226.

Gleason JE, Galaleldeen A, Peterson RL, Taylor AB, Holloway SP, Waninger-Saroni J, Cormack BP, Cabelli DE, Hart PJ, Culotta VC. Candida albicans  SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5866-71. PubMed PMID: 24711423.

Chen H, Choi J, Bailey S. Cut site selection by the two nuclease domains of the Cas9 RNA-guided endonuclease. J Biol Chem. 2014 May 9;289(19):13284-94 PubMed PMID: 24634220.

Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 2014 Mar 13;507(7491):195-200. PubMed PMID: 24598541.

van Steensel MA, Coulombe PA, Kaspar RL, Milstone LM, McLean IW, Roop DR, Smith FJ, Sprecher E, Schwartz ME. Report of the 10th Annual International Pachyonychia Congenita Consortium Meeting. J Invest Dermatol. 2014 Mar;134(3):588-91. PubMed PMID: 24518109. 

Newnham L, Jordan PW, Carballo JA, Newcombe S, Hoffmann E. Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome  integrity during meiosis. PLoS One. 2013 Dec 27;8(12):e83982. PubMed PMID: 24386320.

Copsey A, Tang S, Jordan PW, Blitzblau HG, Newcombe S, Chan AC, Newnham L, Li Z, Gray S, Herbert AD, Arumugam P, Hochwagen A, Hunter N, Hoffmann E. Smc5/6 coordinates formation and resolution of joint molecules with chromosome morphology to ensure meiotic divisions. PLoS Genet. 2013;9(12):e1004071. PubMed PMID: 24385939.

Jayabalasingham B, Voss C, Ehrenman K, Romano JD, Smith ME, Fidock DA, Bosch J, Coppens I. Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage: possible linkage between the apicoplastic and autophagic systems? Autophagy. 2014 Feb;10(2):269-84. PubMed PMID: 24342964.

2013

Bailey S. The Cmr complex: an RNA-guided endoribonuclease. Biochem Soc Trans. 2013 Dec;41(6):1464-7. PubMed PMID: 24256238.

Lessard JC, Piña-Paz S, Rotty JD, Hickerson RP, Kaspar RL, Balmain A, Coulombe PA. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19537-42. PubMed PMID: 24218583.

Ando Y, Leung AK. Does an emergency visit to the ER make microRNAs stronger during stress? Mol Cell. 2013 Oct 10;52(1):1-3. PubMed PMID: 24119397.

Gleason JE, Li CX, Odeh HM, Culotta VC. Species-specific activation of Cu/Zn SOD by its CCS copper chaperone in the pathogenic yeast Candida albicans. J Biol Inorg Chem. 2014 Jun;19(4-5):595-603. PubMed PMID: 24043471.

Boucher LE, Bosch J. Development of a multifunctional tool for drug screening against plasmodial protein-protein interactions via surface plasmon resonance. J  Mol Recognit. 2013 Oct;26(10):496-500. PubMed PMID: 23996492.

Brandt GS, Bailey S. Dematin, a human erythrocyte cytoskeletal protein, is a substrate for a recombinant FIKK kinase from Plasmodium falciparum. Mol Biochem Parasitol. 2013 Sep;191(1):20-3. PubMed PMID: 23973789.

Reiter K, Mukhopadhyay D, Zhang H, Boucher LE, Kumar N, Bosch J, Matunis MJ. Identification of biochemically distinct properties of the small ubiquitin-related modifier (SUMO) conjugation pathway in Plasmodium falciparum. J Biol Chem. 2013 Sep 27;288(39):27724-36. PubMed PMID: 23943616.

Chung BM, Rotty JD, Coulombe PA. Networking galore: intermediate filaments and cell migration. Curr Opin Cell Biol. 2013 Oct;25(5):600-12. PubMed PMID: 23886476.

Kryzak CA, Moraine MM, Kyle DD, Lee HJ, Cubeñas-Potts C, Robinson DN, Evans JP. Prophase I mouse oocytes are deficient in the ability to respond to fertilization by decreasing membrane receptivity to sperm and establishing a membrane block to polyspermy. Biol Reprod. 2013 Aug 29;89(2):44. PubMed PMID: 23863404.

Parks Saldutti L, Beyer BK, Breslin W, Brown TR, Chapin RE, Campion S, Enright B, Faustman E, Foster PM, Hartung T, Kelce W, Kim JH, Loboa EG, Piersma AH, Seyler D, Turner KJ, Yu H, Yu X, Sasaki JC. In vitro testicular toxicity models: opportunities for advancement via biomedical engineering techniques. ALTEX. 2013;30(3):353-77. PubMed PMID: 23861079.

Gómez R, Jordan PW, Viera A, Alsheimer M, Fukuda T, Jessberger R, Llano E, Pendás AM, Handel MA, Suja JA. Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes. J Cell Sci. 2013 Sep 15;126(Pt 18):4239-52. PubMed PMID: 23843628.

Morris F, Vierling R, Boucher L, Bosch J, Freel Meyers CL. DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem. 2013 Jul 22;14(11):1309-15. PubMed PMID: 23824585.

Coulombe PA, Caterina MJ. The incidental pore: CaV1.2 and stem cell activation in quiescent hair follicles. Genes Dev. 2013 Jun 15;27(12):1315-7. PubMed PMID: 23788620.

Mulepati S, Bailey S. In vitro reconstitution of an Escherichia coli RNA-guided immune system reveals unidirectional, ATP-dependent degradation of DNA target. J Biol Chem. 2013 Aug 2;288(31):22184-92. PubMed PMID: 23760266.

Fu K, Sun X, Zheng W, Wier EM, Hodgson A, Tran DQ, Richard S, Wan F. Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells. Nat Commun. 2013;4:1909. PubMed PMID: 23715268.

Aguirre JD, Clark HM, McIlvin M, Vazquez C, Palmere SL, Grab DJ, Seshu J, Hart PJ, Saito M, Culotta VC. A manganese-rich environment supports superoxide dismutase activity in a Lyme disease pathogen, Borrelia burgdorferi. J Biol Chem. 2013 Mar 22;288(12):8468-78. PubMed PMID: 23376276.

Reddi AR, Culotta VC. SOD1 integrates signals from oxygen and glucose to repress respiration. Cell. 2013 Jan 17;152(1-2):224-35. PubMed PMID: 23332757.

Ables ET, Drummond-Barbosa D. Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals. Development. 2013 Feb 1;140(3):530-40. PubMed PMID: 23293285.

Baron JA, Laws KM, Chen JS, Culotta VC. Superoxide triggers an acid burst in Saccharomyces cerevisiae to condition the environment of glucose-starved cells. J Biol Chem. 2013 Feb 15;288(7):4557-66. PubMed PMID: 23281478..

Hain AU, Bosch J. Autophagy in Plasmodium, a multifunctional pathway? Comput Struct Biotechnol J. 2013 Aug 20;8:e201308002. PubMed PMID: 24688742.

Culotta VC, Daly MJ. Manganese complexes: diverse metabolic routes to oxidative stress resistance in prokaryotes and yeast. Antioxid Redox Signal. 2013 Sep 20;19(9):933-44. PubMed PMID: 23249283.

Leung AK, Sharp PA. Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. Adv Exp Med Biol. 2013;768:165-82. PubMed PMID: 23224970.