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Causal Inference in Medicine and Public Health II

4th term
3 credits
Academic Year:
2022 - 2023
Instruction Method:
Synchronous Online
Class Times:
  • Tu Th,  1:30 - 2:50pm
Auditors Allowed:
Yes, with instructor consent
Undergrads Allowed:
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructors:
Constantine Frangakis

140.654 or equivalent for matrix representation of multiple linear and logistic regression


Presents principles, methods, and applications in drawing cause-effect inferences with a focus on the health sciences. Building on the basis of 140.664, emphasizes statistical theory and design and addresses complications and extensions, aiming at cultivating students’ research skills in this area. Includes: detailed role of design for causal inference; role of models and likelihood perspective for ignorable treatment assignment; estimation of noncollapsible causal effects; statistical theory of propensity scores; use of propensity scores for estimating effect modification and for comparing multiple treatments while addressing regression to the mean; theory and methods of evaluating longitudinal treatments, including the role of sequentially ignorable designs and propensity scores; likelihood theory for instrumental variables and principal stratification designs and methods to deal with treatment noncompliance, direct and indirect effects, and censoring by death.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe causal problems as potential interventions, through the framework of potential outcomes and assignment mechanisms
  2. Discuss the role of designs and of different modes of statistical inference
  3. Implement efficient (likelihood) methods with ignorable assignment of treatments
  4. Describe the role of outcome models and of propensity score models
  5. Assess when and how comparisons of longitudinal treatments can be designed as having sequentially ignorable assignment, and learn ways to estimate their causal effects
  6. Master efficient methods for estimating effects in studies with noncompliance to treatment, direct and indirect effects, and censoring by death
Methods of Assessment:

This course is evaluated as follows:

  • 50% Problem sets
  • 50% Final Project

Instructor Consent:

Consent required for some students

Consent Note:

Consent required for undergraduates

For consent, contact:

Special Comments:

Please note: This is the virtual/online section of a course that is also offered onsite. Students will need to commit to the modality for which they register.