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Principles and Methods of Functional Neuroimaging I


East Baltimore
3rd term
4 credits
Academic Year:
2022 - 2023
Instruction Method:
Class Times:
  • M W,  9:00 - 10:20am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructors:
Martin Lindquist

An introductory statistics class and a working knowledge of regression


Introduces the principles of functional magnetic resonance imaging (fMRI) as applied to human subjects research. Presents a theoretical overview of human fMRI research and includes key aspects of the design, data collection, processing, analysis and publication of a human subjects fMRI experiment. Focuses on describing all aspects of an fMRI study from the initial experimental design, through data collection and pre-processing, to statistical analysis. Describes the goals and limitations for fMRI studies, the data format and how it is processed prior to statistical analysis. Focuses on preforming individual subject and group level univariate statistical analysis of fMRI data with appropriate thresholding and multiple comparison correction. Weekly labs provide a practical application of these concepts to sample datasets and prepares students for the analysis of fMRI data.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe key aspects of fMRI experimental design, and design and prepare a human subjects fMRI experiment
  2. Explain the specific methods, source of MR signal, goals and limitations and research design issues for fMRI studies
  3. Import and pre-process fMRI data including slice-timing correction, motion correction and registration
  4. Perform individual subject and group-level univariate statistical analysis of fMRI data with appropriate thresholding and multiple comparison correction
  5. Critically evaluate research methods and results of human subjects fMRI studies in published literature
Methods of Assessment:

Lab assignments (50%) and take-home final exam (50%)

Instructor Consent:

No consent required