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Introduction to Molecular Toxicology

4th term
Environmental Health and Engineering
3 credits
Academic Year:
2021 - 2022
Instruction Method:
Asynchronous Online with Some Synchronous Online
Auditors Allowed:
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructor:
Shyam Biswal

A college level background in the biological sciences. Introduction to Online Learning (550.02.81) Public Health Toxicology (online) (187.610.81) is suggested


Introduces students to toxicology at a molecular level. Reviews the molecular mechanisms of diseases associated with environmental exposures and both genetic and epigenetic changes that are associated with disease pathogenesis. Introduces the cellular signaling pathways involved in protection from effects of chronic exposure to environmental toxicants including responses to stress and oxidative damage. Presents the most recent technological advances in the molecular tools available to study effects of environmental toxicants including next generation sequencing, mass spectrometry, gene editing models and emerging alternative animal models.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe the biological consequences leading to disease pathogenesis in response to toxins in the environment
  2. Relate the genomic pathways by which environmental toxicants regulate gene expression and cell functions
  3. State the stress response to environmental toxicants
  4. Describe how DNA damage and repair contributes to carcinogenesis caused by environmental toxicants
  5. Compare various state-of-the-art techniques including gene editing models and high throughput profiling including genomics, epigenomics, proteomics and metabolomics, and state their applications for toxicological studies and public health research
Methods of Assessment:

This course is evaluated as follows:

  • 50% Quizzes
  • 30% Final Paper
  • 20% Discussion Board

Instructor Consent:

No consent required

Special Comments:

This course is designed for students with minimal background in biology and toxicology.