Skip Navigation

Course Directory

120.606.01
Cellular Stress in Physiology and Disease

Location:
East Baltimore
Term:
4th term
Department:
Biochemistry and Molecular Biology
Credits:
3 credits
Academic Year:
2021 - 2022
Instruction Method:
Synchronous Online
Class Times:
  • Tu Th,  10:30 - 11:50am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructors:
Contact:
Jiou Wang
Resources:
Prerequisite:

Students should have a background of undergraduate or graduate level coursework in Molecular Biology.

Description:

Discuss molecular mechanisms through which eukaryotes maintain cellular homeostasis in response to stress. Stress response pathways are examined at the DNA, RNA, and protein levels; topics include stress and transcription, RNA processing, and protein quality control. Organelle-specific stress response, such as ER stress and mitochondrion stress responses, are also discussed. Additionally, molecular mechanisms of cellular responses to environmental stimuli, such as heat, hypoxic, oxidative, and starvation stressors, are examined.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Understand why the ability to maintain homeostasis in response to environmental stress is critical for cellular survival and functions.
  2. Overview the current understanding of stress response pathways at the DNA, RNA, and protein levels
  3. Examine organelle-specific stress response, such as ER stress and mitochondrion stress responses.
  4. Understand the mechanisms through which cells adapt to heat, osmotic, hypoxic, oxidative, and starvation stresses.
Methods of Assessment:

This course is evaluated as follows:

  • 40% Midterm
  • 40% Final Exam
  • 20% Discussion

Enrollment Restriction:

All undergraduate students require consent before registering for this course

Instructor Consent:

Consent required for some students

Consent Note:

All undergraduate students require consent before registering for this course

For consent, contact:

jiowang@jhsph.edu