Skip Navigation

Course Directory

Principles of Clinical Epidemiology


East Baltimore
2nd term
2 credits
Academic Year:
2021 - 2022
Instruction Method:
Synchronous Online
Class Times:
  • Tuesday,  8:00 - 10:20am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructor:
Kunihiro Matsushita

340.751 (Epidemiologic Methods 1)


Presents lectures and interactive sessions designed to expose students to basic principles of clinical epidemiology and introduce key methods utilized in clinical outcomes research. Focuses on principles and methods in clinical epidemiology which would be most utilized by clinicians/clinician researchers for screening and diagnosis of illness as well as for prognostication and decision-making.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe how epidemiological methods are applied to medicine and how scientific evidence drive decision on clinical practice.
  2. Draw a ROC curve to understand and estimate the effect and implications of different cutoff points in diagnostic test
  3. Evaluate the performance of diagnostic tests taking into account characteristics of the test (sensitivity, specificity, etc.), potential outcomes and the features of the population (prevalence of disease and risk factors)
  4. Describe key factors for deciding optimal outcome measures for a clinical study
  5. Describe advantages and disadvantages of clinical trials and observational studies for evaluating treatment effects
  6. Build a decision analysis tree based on probabilities and see how different outcomes influence the decision making in clinical settings
Methods of Assessment:

This course is evaluated as follows:

  • 15% Participation
  • 60% Homework
  • 25% Final Project

Instructor Consent:

No consent required