120.606.01
Cellular Stress in Physiology and Disease
Location
East Baltimore
Term
4th Term
Department
Biochemistry and Molecular Biology
Credit(s)
3
Academic Year
2019 - 2020
Instruction Method
TBD
Tu, Th, 10:30 - 11:50am
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
Yes
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Contact Name
Frequency Schedule
Every Year
Resources
Prerequisite
Students should have a background of undergraduate or graduate level coursework in Molecular Biology.
Discuss molecular mechanisms through which eukaryotes maintain cellular homeostasis in response to stress. Examines tress response pathways at the DNA, RNA, and protein levels; topics include stress and transcription, epigenetics, RNA processing, and protein quality control. Organelle-specific stress response, such as ER stress and mitochondrion stress responses, are also discussed. Additionally, examines molecular mechanisms of cellular responses to environmental stimuli, such as heat, osmotic, hypoxic, oxidative, and starvation stressors.
Learning Objectives
Upon successfully completing this course, students will be able to:
- Describe the basics for how cells sense and respond to a wide variety of cellular stress agents and maintain fitness and survival through quality control
- Understand the basis for state-of-the-art laboratory approaches to research the molecular and cellular biology of stress and quality control
- Examine organelle-specific stress response, such as ER stress and mitochondrion stress responses.
- Understand the mechanisms through which cells adapt to heat, osmotic, hypoxic, oxidative, and starvation stresses
Enrollment Restriction
All undergraduate students require consent before registering for this course