187.645.81 Toxicology 21: Scientific Applications
- Department:
- Environmental Health and Engineering
- Term:
- 3rd term
- Credits:
- 3 credits
- Academic Year:
- 2019 - 2020
- Location:
- Internet
- Auditors Allowed:
- Yes, with instructor consent
- Grading Restriction:
- Letter Grade or Pass/Fail
- Contact:
- Lena Smirnova
- Course Instructor :
- Resources:
- Prerequisite:
Introduction to Online Learning is required prior to participating in any of the School's Internet-based courses. 187.632 Molecular toxicology; Background in molecular and cell biology recommended
- Description:
-
Familiarizes students with the novel concepts being used to revamp regulatory toxicology in response to a breakthrough National Research Council Report “Toxicity Testing in the 21st Century: A Vision and a Strategy.” Presents the latest developments in the toxicology field: moving away from animal testing toward human relevant, high content, high throughput integrative testing strategies. Active programs from EPA, NIH and the scientific community work-wide illustrate the dynamics of safety sciences.
- Learning Objectives:
-
Upon successfully completing this course, students will be able to:
- Debate and criticize the shortcomings of the current approach to hazard assessment
- Evaluate the technologies entering the regulatory arena
- Explain the challenges of toxicology 21st century to change the paradigm in toxicology
- Explain mechanism of toxicity and toxicokinetics as the basis for testing strategies
- Describe novel types of data and bioinformatics entering regulatory evaluations
- Implement Tox21 (PubChem, Data Visualization and integration suites) and ToxCast (iCSS Dashboard) interactive web applications to mine and assess Tox21 and ToxCast high-throughput chemical screening data
- Methods of Assessment:
Midterm 40%, Final exam 40%, Assignments 20% (two assignments where student will work on the home project with interactive ToxCast web application to learn how to mine high-throughput chemical testing data
- Instructor Consent:
No consent required