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Introduction to Molecular Toxicology

4th term
Environmental Health and Engineering
3 credits
Academic Year:
2018 - 2019
Instruction Method:
Auditors Allowed:
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructors:
Winnie Tang

A college level background in the biological sciences. Introduction to Online Learning (550.02.81) Public Health Toxicology (online) (187.610.81) is suggested


‘Introduction to Molecular Toxicology’ is a 3-credit online course that introduces toxicology at a molecular level. It is designed for students with minimal background in biology and toxicology. The course will review the molecular mechanisms of diseases associated with environmental exposures. The course will introduce the cellular signaling pathways involved in protection from effects of chronic exposure to environmental toxicants, including responses to stress and oxidative damage. The course will also review both genetic and epigenetic changes that are associated with disease pathogenesis. In addition, the course will present the most recent technological advances in the molecular tools available to study effects of environmental toxicants, including next generation sequencing, mass spectrometry, gene editing models and emerging alternative animal models.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. •Describe the biological consequences leading to disease pathogenesis in response to toxins in the environment
  2. •Relate the genomic pathways by which environmental toxicants regulate gene expression and cell functions
  3. •State the stress response to environmental toxicants
  4. •Describe how DNA damage and repair contributes to carcinogenesis caused by environmental toxicants
  5. •Compare various state-of-the-art techniques including gene editing models and high throughput profiling including genomics, epigenomics, proteomics and metabolomics, and state their applications for toxicological studies and public health research
Methods of Assessment:

Three Graded Discussion Board Assignments 60%; Final exam (graded essay) 40%

Instructor Consent:

No consent required