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Molecular Toxicology

East Baltimore
2nd term
Environmental Health and Engineering
4 credits
Academic Year:
2018 - 2019
Instruction Method:
Class Times:
  • M W F,  10:30 - 11:50am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructors:
Winnie Tang

A basic course in molecular biology or consent of instructor


Reviews the mechanisms by which environmental toxicants cause chronic diseases such as cancer, COPD, asthma and heart diseases that impact public health. Topics include cell signaling pathways involved in oxidative and nitrosative stress, cell growth, cell death, DNA repair, inflammation and carcinogenesis in response to exposure to air pollutants, metals and other environmental toxicants. Presents most recent technological advances in the molecular and genetic tools available to study how environmental toxicants cause diseases, which includes omics technologies (genomics, proteomics and metabolomics), next-generation sequencing for gene expression and genetic variations, transgenic animals and emerging alternative animal models.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Analyze and discuss the literature regarding a wide array of topics relevant to molecular toxicology, including the molecular response to environmental stress and pathways of carcinogenesis and DNA repair
  2. Describe various gene-environment interactions that lead to either cell adaptation, cell death or disease in response to toxins in the environment
  3. Discuss the application of various state-of-the-art techniques for molecular analyses, including genomics, proteomics and metabolomics, next-gen sequencing, transgenic animal model and alternative animal models for research
Methods of Assessment:

Midterm 35%; Final exam 35%; Participation 30%

Instructor Consent:

No consent required

Special Comments:

MSPH Track in Toxicity Testing and Human Health Risk Assessment & MHS in Environmental Health, HTP track Students must take 187.640 Toxicology 21: Scientific Foundations concurrently. Students in other programs are encouraged to do the same.