120.606.01 Cellular Stress in Physiology and Disease
- Biochemistry and Molecular Biology
- 4th term
- 3 credits
- Academic Year:
- 2017 - 2018
- East Baltimore
- Class Times:
- Tu Th, 10:30 - 11:50am
Students should have a background of undergraduate or graduate level coursework in Molecular Biology.
Discuss molecular mechanisms through which eukaryotes maintain cellular homeostasis in response to stress. Examines tress response pathways at the DNA, RNA, and protein levels; topics include stress and transcription, epigenetics, RNA processing, and protein quality control. Organelle-specific stress response, such as ER stress and mitochondrion stress responses, are also discussed. Additionally, examines molecular mechanisms of cellular responses to environmental stimuli, such as heat, osmotic, hypoxic, oxidative, and starvation stressors.
- Learning Objectives:
- Describe the basics for how cells sense and respond to a wide variety of cellular stress agents and maintain fitness and survival through quality control
- Understand the basis for state-of-the-art laboratory approaches to research the molecular and cellular biology of stress and quality control
- Examine organelle-specific stress response, such as ER stress and mitochondrion stress responses.
- Understand the mechanisms through which cells adapt to heat, osmotic, hypoxic, oxidative, and starvation stresses
- Methods of Assessment:
This course is evaluated as follows: 40% mid-term exam, 50% final exam and 10% class participation.
- Instructor Consent:
Consent required for all students
- Consent Note:
Contact instructor for consent.
- For consent, contact: