Skip Navigation

Course Catalog

120.624.01 Cancer Biology

Department:
Biochemistry and Molecular Biology
Term:
4th term
Credits:
3 credits
Academic Year:
2017 - 2018
Location:
East Baltimore
Class Times:
  • M W,  3:30 - 4:50pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Fengyi Wan
Course Instructor:
  • Fengyi Wan
Resources:
Description:

Presents the molecular and cellular mechanisms in the biology of cancer. Topics include Oncogenes and tumor suppressor genes, DNA damage responses, p53 signaling pathway, NF-kB signaling pathway, chemotherapy and radiotherapy, and several key research fields in major select human cancers. Emphasizes the relevance of these mechanisms to the development and treatment of human cancer.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Understand the key hallmarks associated with cancer development
  2. Understand how exposure to various environmental agents could lead to carcinogenesis in normal cells and how chemotherapy- and radiotherapy-based anti-cancer drugs can kill cancer cells
  3. Define the cellular signaling cascade in response to environmental and intrinsic DNA damage in normal and cancer cells
  4. Define the importance of several key signaling pathways in the cellular response to DNA damage
  5. Understand the mechanisms by which the cell determines the fate for survival and death
  6. Understand the current research in major select human cancers
Methods of Assessment:

Student evaluation based on class participation (20%) and two in-class written exams (mid-term 40% and final 40%).

Enrollment Restriction:

Undergraduates prohibited from enrolling in this course.

Instructor Consent:

Consent required for all students

Consent Note:

Consent required.

For consent, contact:

fwan1@jhu.edu