- East Baltimore
- 4th term
- Biochemistry and Molecular Biology
- 3 credits
- Academic Year:
- 2017 - 2018
- Class Times:
- M W, 3:30 - 4:50pm
Presents the molecular and cellular mechanisms in the biology of cancer. Topics include Oncogenes and tumor suppressor genes, DNA damage responses, p53 signaling pathway, NF-kB signaling pathway, chemotherapy and radiotherapy, and several key research fields in major select human cancers. Emphasizes the relevance of these mechanisms to the development and treatment of human cancer.
- Learning Objectives:
- Understand the key hallmarks associated with cancer development
- Understand how exposure to various environmental agents could lead to carcinogenesis in normal cells and how chemotherapy- and radiotherapy-based anti-cancer drugs can kill cancer cells
- Define the cellular signaling cascade in response to environmental and intrinsic DNA damage in normal and cancer cells
- Define the importance of several key signaling pathways in the cellular response to DNA damage
- Understand the mechanisms by which the cell determines the fate for survival and death
- Understand the current research in major select human cancers
- Methods of Assessment:
Student evaluation based on class participation (20%) and two in-class written exams (mid-term 40% and final 40%).
- Enrollment Restriction:
Undergraduates prohibited from enrolling in this course.
- Instructor Consent:
Consent required for all students
- Consent Note:
- For consent, contact: