223.689.01
Biologic Basis of Vaccine Development

Location
East Baltimore
Term
4th Term
Department
International Health
Credit(s)
3
Academic Year
2017 - 2018
Instruction Method
TBD
Class Time(s)
M, W, 3:30 - 4:50pm
Auditors Allowed
Yes, with instructor consent
Available to Undergraduate
No
Grading Restriction
Letter Grade or Pass/Fail
Course Instructor(s)
Anna Durbin
Jay Bream
Course Instructor(s)
August Bourgeois
Contact Name
Anna Durbin
Contact Email
adurbin1@jhu.edu
Frequency Schedule
Every Year
Prerequisite

260.611-612, or equivalent familiarity with the principles of immunology

Description
Provides an overview of the biologic basis for development and evaluation of new viral, bacteriologic, parasitic, and cancer vaccines. Lectures address the fundamental immunologic concepts of correlates of protective immunity underlying current and new strategies for immunization. Emphasizes the use of new technologies for expression of vaccine antigens, including recombinant DNA techniques and use of novel adjuvants and antigen-carrier systems to enhance the delivery/presentation of specific immunogens to effector sites.
Learning Objectives
Upon successfully completing this course, students will be able to:
  1. Identify and describe the biological obstacles preventing development of effective vaccines for several important human pathogens
  2. Identify, analyze, and critique cutting-edge strategies for approaching these obstacles
  3. Describe several molecular mechanisms by which various adjuvants may potentiate vaccine induced immune responses
  4. Identify and explain multiple differences between the natural immune response to pathogens and the vaccine induced immune response to targeted antigens
  5. Analyze and explain the implications for bio-defense of vaccine related work on various pathogens
  6. Describe the advantages and disadvantages of several viral and bacterial vectors for the delivery of recombinant vaccine antigens or DNA
  7. Discuss the three signals necessary to trigger a primary immune response to a candidate vaccine antigen
  8. Discuss the important role that vaccine type (i.e. live vs. killed vs. subunit) and route of administration (IM vs. ID) can play in determining the types of immune responses elicited by immunization
Instructor Consent
No consent required
Consent Contact
adurbin1@jhu.edu
Jointly Offered With
Molecular Microbiology and Immunology