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Biologic Basis of Vaccine Development

East Baltimore
4th term
International Health
3 credits
Academic Year:
2017 - 2018
Class Times:
  • M W,  3:30 - 4:50pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructor s:
Anna Durbin

260.611-612, or equivalent familiarity with the principles of immunology


Provides an overview of the biologic basis for development and evaluation of new viral, bacteriologic, parasitic, and cancer vaccines. Lectures address the fundamental immunologic concepts of correlates of protective immunity underlying current and new strategies for immunization. Emphasizes the use of new technologies for expression of vaccine antigens, including recombinant DNA techniques and use of novel adjuvants and antigen-carrier systems to enhance the delivery/presentation of specific immunogens to effector sites.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Identify and describe the biological obstacles preventing development of effective vaccines for several important human pathogens
  2. Identify, analyze, and critique cutting-edge strategies for approaching these obstacles
  3. Describe several molecular mechanisms by which various adjuvants may potentiate vaccine induced immune responses
  4. Identify and explain multiple differences between the natural immune response to pathogens and the vaccine induced immune response to targeted antigens
  5. Analyze and explain the implications for bio-defense of vaccine related work on various pathogens
  6. Describe the advantages and disadvantages of several viral and bacterial vectors for the delivery of recombinant vaccine antigens or DNA
  7. Discuss the three signals necessary to trigger a primary immune response to a candidate vaccine antigen
  8. Discuss the important role that vaccine type (i.e. live vs. killed vs. subunit) and route of administration (IM vs. ID) can play in determining the types of immune responses elicited by immunization
Methods of Assessment:

first assignment = 25%,
second assignment = 30%,
third assignment = 30%,
attendance = 15%

Instructor Consent:

No consent required

Jointly Offered With: