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Course Catalog

180.640.01 Molecular Epidemiology and Biomarkers in Public Health

Department:
Environmental Health and Engineering
Term:
3rd term
Credits:
4 credits
Academic Year:
2017 - 2018
Location:
East Baltimore
Class Times:
  • Tu Th,  3:00 - 4:20pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Paul Strickland
Course Instructor:
Resources:
Prerequisite:

340.601-602 or consent of instructor

Description:

Emphasizes the scientific basis of molecular epidemiology and provides examples of the application of molecular biology, analytical chemistry, and toxicology to the study of chronic disease etiology and its public health application, including examples in human cancer, cardiovascular, immunological, and neurological diseases. Also discusses methodological and study design problems.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe how and when molecular and chemical biomarkers can be applied in public health biomonitoring and in epidemiological studies
  2. Articulate the difference between biomarkers of exposure, dose, effect, and susceptibility in various chronic diseases
  3. Discuss methodological and study design problems in applying biomarkers in epidemiological studies
  4. Compare the attributes and deficiencies of particular biomarker assays for biomonitoring and molecular epidemiology
  5. Determine if you should sacrifice banked serum samples to analysis by a particular biomarker assay
  6. Explain the importance of the half-life of a biomarker to an epidemiological study design
  7. Discuss the validation process for new biomarkers prior to application in formal studies
Methods of Assessment:

Student evaluation based on a paper (50%) and a final exam (50%).

Instructor Consent:

No consent required

Jointly Offered With:
Special Comments:

Additional 1 hour TBA