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Course Catalog

187.640.01 Toxicology 21: Scientific Foundations

Department:
Environmental Health and Engineering
Term:
2nd term
Credits:
1 credit
Academic Year:
2017 - 2018
Location:
East Baltimore
Class Times:
  • Wednesday,  3:30 - 4:20pm
Auditors Allowed:
No
Grading Restriction:
Letter Grade or Pass/Fail
Contact:
Joseph Bressler
Course Instructors:
Resources:
Prerequisite:

187.610 Public Health Toxicology

Description:

Provides students with fundamental knowledge of the emerging science driving new strategies for human risk assessment. Topics include toxicokinetics, xenobiotic activation and inactivation, systems biology, and databases for toxicity testing. Presents case studies that have used different data bases for toxicity testing. Students have hands-on experiences using the databases and other Web-based applications.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Discuss the metabolism of xenobiotics
  2. Apply the principles of xenobiotic metabolism and drug-drug interaction to pharmacokinetics and toxicokinetics
  3. Explain the basis of differences in xenobiotic metabolism in different populations
  4. Analyze the scientific evidence for the development of new toxicity testing strategies
Methods of Assessment:

50% two exams (combination of multiple choice and short answers-5-6 lines); 20% participation (including an assigned oral presentation on a signaling pathway that is involved in responses to xenobiotics); 30% assignment (Critically evaluate the scientific basis of a testing paradigm that is currently in pre-validation phase).

Instructor Consent:

Consent required for some students

Consent Note:

Consent required for students not in the MSPH Track in Toxicity Testing and Human Health Risk Assessment or MHS in Environmental Health, HTP focus area.

For consent, contact:

jbressl1@jhu.edu

Special Comments:

MSPH Track in Toxicity Testing and Human Health Risk Assessment & MHS in Environmental Health, HTP track Students must take 187.632 Molecular Toxicology concurrently. Course will be held in departmental space.