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140.754.01 Advanced Methods in Biostatistics IV

4th term
4 credits
Academic Year:
2015 - 2016
East Baltimore
Class Times:
  • Tu Th,  10:30 - 11:50am
Lab Times:
  • Tuesday,  9:00 - 10:20am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Hong Kai Ji
Course Instructor:



Extends topics in 140.753 to encompass generalized linear mixed effects models and introduces nonparametric smoothing, functional data analysis and data mining. Foundational topics include: linear mixed model, generalized linear mixed model, models for longitudinal data, prediction and classification, and functional data analysis. Emphasizes both rigorous methodological development and practical data analytic strategies. Related computational methods and skills developed in the concurrent computing/data lab.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Use modern statistical concepts such as linear mixed model (LMM) and generalized linear mixed models (GLMM) for inference
  2. Describe the relationship between LMM and GLMM
  3. Extend models to account for clustering and correlation
  4. Learn techniques for solving prediction problems
  5. Understand and use nonparametric smoothing models
  6. Describe modern statistical methods for complex datasets including functional data analysis and data mining
  7. Improve computational and analytic skills through analysis of simulated and real data sets
Methods of Assessment:

Homework (70%) and a final exam (30%)

Instructor Consent:

No consent required