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260.714.01 Immunogenetics


Molecular Microbiology and Immunology
4th term
3 credits
Academic Year:
2014 - 2015
East Baltimore
Class Times:
  • Tu Th,  1:30 - 2:50pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Noel Rose
Frequency Schedule:
Every Other Year

260.611-612 or introductory course in immunology; introductory course in genetics


Presents the genetic basis of immune responsiveness. Reviews the genetic mechanisms responsible for generation of diversity in the genes for immunoglobulins, the T cell receptor molecules, the major histocompatibility molecules, and other key molecules of the immuno-globulin superfamily. Discusses mechanisms and statistical evaluation of immunogenetic associations with susceptibility or resistance to disease.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Define the genetic systems that encode molecules with integral roles in immune regulation
  2. Assess the impact of allelic polymorphism in certain genes on features such as gene expression and MHC restriction
  3. Define the basic mechanisms for expansion of the immunologic repertoire of antigen receptors
  4. Understand the implications of population differences in the frequencies of genes involved in immune responses
Methods of Assessment:

Student evaluation based on a mid-term exam, and a final exam, or paper and oral presentation.

Instructor Consent:

No consent required