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Course Catalog

260.608.01 Advanced Topics in AIDS Research


Molecular Microbiology and Immunology
4th term
4 credits
Academic Year:
2014 - 2015
East Baltimore
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructor:
  • Xiaofang Yu
Frequency Schedule:
Every Other Year

PH 260.623 or instructor consent


Introduces students to the HIV lifecycle and the molecular events occurring during productive infection. Covers topics including the HIV life cycle (Entry, Reverse transcription, Integration, Assembly, Budding, and Maturation), viral regulatory proteins, host innate anti-HIV responses (Apobec and Trim5á), immune responses induced by vaccine and infection, recent progress in HIV vaccine development, origins of HIV, SIV, endogenous retroviruses, new insights in HIV pathogenesis, host factors influencing disease outcome, latency and persistence, transmission, and prophylactic strategies of prevention.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Define points of the viral lifecycle at which host proteins interfere with viral infection
  2. Understand replication cycle of HIV and contrast with other retroviruses
  3. Assess current vaccine strategies
  4. Analyze current literature
  5. Explain the influence of host factors on disease outcome
Methods of Assessment:

Evaluation is based on class participation, core discussion, and a final exam.

Instructor Consent:

Consent required for all students

For consent, contact: