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Course Catalog

187.610.11 Public Health Toxicology


Environmental Health and Engineering
Summer Inst. term
4 credits
Academic Year:
2014 - 2015
East Baltimore
Mon 06/09/2014 - Fri 06/20/2014
Class Times:
  • M Tu W Th F,  8:30 - 11:50am
Auditors Allowed:
Grading Restriction:
Letter Grade or Pass/Fail
Michael Trush
Course Instructors:
Frequency Schedule:
One Year Only

Background in college biochemistry and cell biology strongly encouraged.


Students examine basic concepts of toxicology as they apply to the effects of environmental agents, e.g. chemicals, metals, on public health. We discuss the distribution, cellular penetration, metabolic conversion, and elimination of toxic agents, as well as the fundamental laws governing the interaction of foreign chemicals with biological systems. Students focus on the application of these concepts to the understanding and prevention of morbidity and mortality resulting from environmental exposures to toxic substances through a case study format.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe the chemical properties and the biological processes which modulate the toxicokinetics of chemical agents of public health importance
  2. Explain the significance of biotransformation reactions as a determinant of the toxicokinetic and toxicodynamic activities of chemicals
  3. Describe molecular, cellular and pathophysiological responses resulting from exposure to chemical agents relevant to human health
  4. Identify underlying susceptibility factors which contribute to the ability of chemicals to elicit bioeffects which contribute to human disease
  5. Explain the science underlying testing for the ability of chemicals to elicit adverse human health effects
  6. Put into perspective the role of toxicology in the risk assessment process
  7. Discuss in depth the toxicology of selected organs and agents
Methods of Assessment:

Student evaluation is based on six on-line quizzes at 12 points each, two individual written assignments at 30 and 50 points, a mid-course and final exam at 100 points each.

Instructor Consent:

No consent required