Nucleic Acid Chemistry
- East Baltimore
- 3rd term
- Biochemistry and Molecular Biology
- 3 credits
- Academic Year:
- 2013 - 2014
- Class Times:
- M W, 3:30 - 4:50pm
Organic Chemistry and Biochemistry and/or Molecular Biology
Discusses nucleic acid structure, and also describes techniques for manipulating and analyzing nucleic acids, including gel electrophoresis, PCR, and DNA sequencing. Reviews methods used to synthesize nucleosides, nucleotides and oligonucleotides, and chemical reactions that lead to modifications of nucleic acids. Additional topics include: nucleic acid molecular beacons and molecular wires; antisense and antigene oligonucleotides; nucleic acid nanostructures and "machines", and nucleic acid aptamers.
- Learning Objectives:
- Design schemes to synthesize nucleosides and oligonucleotides
- Predict the products of reactions between nucleic acids and various chemical agents, ionizing and ultraviolet radiation
- Understand the design and function of antisense, antigene and siRNAs
- Understand the design and synthesis of nucleic acid nanostructures and machines
- Understand how nucleic acid aptamers are applied to biological problems
- Methods of Assessment:
Final exam at end of term.
- Enrollment Restriction:
Undergraduate students are prohibited from registering for this course.
- Instructor Consent:
Consent required for all students
- Consent Note:
Student should contact instructor for consent to take course.
- For consent, contact: