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Course Catalog

120.624.01 Genome Integrity and Cancer

Biochemistry and Molecular Biology
4th term
3 credits
Academic Year:
2012 - 2013
East Baltimore
Class Times:
  • M W,  3:30 - 4:50pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Paul Miller
Course Instructor:

Graduate level molecular biology, and biochemistry or the equivalent.


Examines molecular mechanisms devoted to the preservation of genome integrity eukaryotic cells. Topics include DNA damage recognition, DNA repair pathways, cell cycle checkpoint mechanisms, the role of p53 in DNA damage responses, the role of ubiquitination and sumoylation in DNA repair, telomere maintenance and DNA repair proteins as target for therapeutic intervention. Emphasizes the relevance of these mechanisms for human cancer.

Learning Objectives:

This course will prepare you to be able to do the following:

  1. Understand how exposure to various environmental agents and anti-cancer drugs can lead to modifications of DNA
  2. Understand the mechanisms by which DNA repair proteins and enzymes maintain the integrity of the genome
  3. Understand how DNA protection and repair systems function in the context of the cell
  4. Understand the connections between DNA damage/DNA repair capacity and human disease, particularly cancer
Methods of Assessment:

Two in-class exams.

Enrollment Restriction:

Undergraduates prohibited from enrolling in this course.

Instructor Consent:

Consent required for all students

Consent Note:

Consent required.

For consent, contact: