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Course Catalog

120.608.01 Genomics for Public Health

Biochemistry and Molecular Biology
4th term
3 credits
Academic Year:
2012 - 2013
East Baltimore
Class Times:
  • Tu Th,  1:30 - 2:50pm
Lab Times:
  • Tu Th,  1:30 - 2:50pm
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Roger McMacken
Course Instructors:

A college level course in biology.


Introduces genomics and modern genetic technologies, emphasizing their application to significant public health problems, to students who have limited prior coursework in molecular biology or molecular genetics. Integrates lectures and discussions with computer exercises in laboratory sessions. Topics include fundamental principles of molecular biology; genome sequencing and structure; gene cloning; mapping of human disease genes; use of DNA microarrays, protein microarrays, and next generation rapid DNA sequencing methodologies in analysis and treatment of human disease; comparative genomics of model and pathogenic organisms; epigenomics and metagenomics; and genetically modified organisms.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. Describe the organization of the human genome and the genomes of selected model organisms
  2. Explain how human disease genes are mapped
  3. Analyze DNA, RNA, or protein sequences through the use of public domain databases and algorithms
  4. Explain how DNA microarrays, protein microarrays, and rapid whole-genome-sequencing technologies can be used to analyze or treat human disease in individuals and populations
  5. Describe basic recombinant DNA, proteomic, and biotechnological methodologies used in the analysis of human disease
  6. Explain how modifications to chromatin or the presence of gut microbial flora impact expression of selected human genes.
Methods of Assessment:

Student evaluation based on four online quizzes (1/4 of total), two computer lab exercises (1/4 of total) and a final exam (1/2 of total).

Instructor Consent:

No consent required