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Advanced Methods in Biostatistics III

East Baltimore
3rd term
3 credits
Academic Year:
2012 - 2013
Instruction Method:
Class Times:
  • Tu Th,  10:30 - 11:50am
Auditors Allowed:
Yes, with instructor consent
Grading Restriction:
Letter Grade or Pass/Fail
Course Instructor:
Jeffrey Leek

140.751-752; Students must also register for 140.754


Introduces the General Linear Model and Generalized Least Squares. Develops the Generalized Likelihood Ratio Test (GLRT) and connects it to the Gaussian Linear Model. Defines Fisher Information and Observed Information. Compares methods of simultaneous inference and multiple comparisons. Covers robust variance estimation. Compares optimal statistical weights to optimal policy weights, and missing data theory and practice. Develops consequences of departures from assumptions, efficiency and robustness trade-offs in the context of missing data and correlated responses. Identifies implications for design, and outlines basic experimental designs, choice of design and analysis, fixed and random effects, Introduces shrinkage estimates. Covers study designs that account for uncertainty in input parameters. Introduces sample reuse via the jackknife and adds to criteria to use in evaluating a procedure and how to identify when a new method or adaptation is needed.

Learning Objectives:

Upon successfully completing this course, students will be able to:

  1. give examples of different types of data arising in public health studies
  2. Discuss differences and similarities between standard linear regression and models for discrete outcomes
  3. use modern statistical concepts such as generalized linear models for inference
  4. apply theoretical concepts to scientific data using R and WinBUGS software
  5. conduct and interpret logistic, conditional logistic, and probit regression inference
  6. extend models to account for clustering
  7. expand the set of biostatistical models with quasi-likelihood, beta-binomial and log-linear models
  8. improve computational and analytic skills through analysis of simulated data sets
Methods of Assessment:

Student evaluation based on homework and a final exam.

Instructor Consent:

No consent required

Special Comments:

Grade for 140.753 and 754 given at completion of 140.754