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Research Studies and Other Projects

The research environment of the Center is multi-institutional, involving faculty and collaboration across multiple departments in the Johns Hopkins Bloomberg School of Public Health, the School of Medicine, and other institutions. Research activities include the design, conduct, and analysis of clinical trials; performance of systematic reviews and meta-analysis of the research evidence; methodological work, such as studies of bias in study design and dissemination of results; and examination of the language and nomenclature of trials.

The subject matter of the clinical trials and systematic reviews conducted by the Center covers a variety of health conditions including but not limited to the ocular complications of AIDS, uveitis, non-arteritic anterior ischemic optic neuropathy, Alzheimer's disease, childhood asthma, emphysema, Barrett's esophagus, non-alcoholic steatohepatitis, and dysfunctional uterine bleeding.

Listed below are current or recent research studies:

Clinical Trials/Followup Studies

Center CV- updated June 2014


American Lung Association - Asthma Clinical Research Centers (ALA-ACRC)

  • Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients with Asthma (CPAP)
  • Long-acting Beta Agonist Step-Down Study (LASST)
  • Study of Asthma and Nasal Steroids (STAN)
  • Study of Soy Isoflavones in Asthma (SOYA)
  • Study of Acid-Reflux in Childhood Asthma (SARCA)

Aprepitant for the Relief of Nausea in Patients with Chronic Nausea and Vomiting of Presumed Gastric Origin Trial (APRON)
Broccoli Sprout Extracts Treatment Trial (BEST)
Cysteamine Bitartrate Delayed-Release for the Treatment of NAFLD in Children (CyNCh)
The Farnesoid X Receptor Ligand Obeticholic Acid in NASH Treatment (FLINT) Trial
Long-term Oxygen Treatment Trial (LOTT)
The Tinnitus Retraining Therapy Trial (TRTT)
Biomarkers of Cognitive Decline Among Normal Individuals: the BIOCARD Cohort Study Extension (BIOCARD-SE)

Completed in the Past Five Years

Alzheimer's Disease Anti-Inflammatory Prevention Trial, Follow-up Study (ADAPT-FS)
Methacholine Bronchopravocation Influence of High Potency Inhaled Corticosteroids in Asthma (MeCIS)
Multicenter Uveitis Steroid Treatment Trial (MUST)
Nortriptyline for Idiopathic Gastroparesis Trial (NORIG)

Sleep Heart Health Study (SHHS)

The Studies of Ocular Complications of AIDS (SOCA)
Treatment of Nonalcoholic Fatty Liver Disease in Children (TONIC)
Citalopram for Agitation in Alzheimer's Disease (CitAD)
Apathy in Dementia Methylphenidate Trial (ADMET)

Evidence Synthesis

Systematic Reviews

Cochrane Collaboration Eyes and Vision Group (CEVG)
United States Cochrane Center (USCC)

Methods Research

Integrating Multiple Data Sources for Meta-Analysis to Improve Patient-Centered Outcomes Research (MuDS)
Consolidated Standards of Reporting Trials- Extension for Social and Psychological Interventions (CONSORT-SPI)
A network meta-analysis of medical treatment for glaucoma (NIH RePORTER link)
Evidence Gap (E-GAP)

  • We examine the recommendations from the American Academy of Ophthalmology clinical practice guidelines (PPPs), see where there are evidence gaps, and ask stakeholders to prioritize the order in which we conduct systematic review and clinical trials. Specialty areas completed: open angle glaucoma, angle closure glaucoma. Specialty areas under study: diabetic retinopathy, macular degeneration, dry eye.

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