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Center for Clinical Trials and Evidence Synthesis Journal Club

The CCTES journal club aims to stimulate student interest, discussion and research into issues related to clinical trials and systematic reviews. Topics include trial design and data analysis; meta-analysis; medical, ethical or legal issues; data entry, management and history of clinical trials.

Schedule for 2015-2016

Schedule: Third Thursday of the month, 12:00 - 1:30PM
Location: See Below
Faculty advisors: Dr. Roberta Scherer and Dr. Lea Drye
Student coordinators: Ben Rouse and Nicole Fusco

 

Access to reading materials:
1. Go to Epi Journal Club Welch e-Reserves.
2. Click on the folder named “Clinical Trials Journal Club”.
3. Download folder contents.

 

Date
Location
Topic, Trial, Systematic ReviewStudent/Postdoc Discussant(s)Faculty Discussant(s)
September 17, 2015
E6519
The AZT Trial and FDA approval (readings)Nicole Fusco
 
Lea Drye
 
October 15, 2015
W2017
The SUPPORT Trial
(readings)
Gillian Gresham
 
Dave Shade
 
November 19, 2015
E9519
The TAPE Trial and the Placebo Effect (readings)Jimmy Le
 
Janet Holbrook
 
December 17, 2015
E6519
Flibanserin Approval (readings)
 
Sheriza Baksh
 
Evan Mayo Wilson/Caleb Alexander
 
February 18, 2016
W3011
The SPRINT Trial (readings)
 
Amie Park
 
Ian Saldanha
 
March 24, 2016
E9519
The SPORT Trial (readings)
 
Jiajun Wen
 
Stephan Ehrhardt
 
April 21, 2016
W2029
Randomized Trials and Complex Interventions (readings)
 
Ben Rouse
 
Bobbi Scherer
 
May 12, 2016
E6519
The LEAP Trial (readings)
 
Yujiang Chen/Ling Yang
 
Tianjing Li
 

Readings:

Journal Club DateReferences
September 17, 2015
E6519





 

Required reading:
1.  Volberding PA et al.  Zidovudine in asymptomatic human immunodeficiency virus infection.  A controlled trial
in persons with fewer than 500 CD4-positive cells per cubic millimeter.  The AIDS Clinical Trials Group of the National Institute of Allergy and Infectious Diseases.  N Engl J Med. 1990;322(14):941-9. 
http://www.ncbi.nlm.nih.gov/pubmed/1969115

Optional reading:
1.  Aboulker JP and Swart AM.  Preliminary analysis of the Concorde trial.  Concorde Coordinating Committee.  Lancet.  1993;341(8849):889-90.
http://www.ncbi.nlm.nih.gov/pubmed/8096582

October 15, 2015
W2017















 

Required reading:
1.  Lantos JD.  Vindication for SUPPORT.  N Engl J Med.  2015 Oct 8;373(15):1393-1395.  Epub 2015 Sep 2.
PubMed PMID: 26332442.  http://www.ncbi.nlm.nih.gov/pubmed/26332442

2.  Drazen JM, Solomon CG, Morrissey S,  Greene MF.  Support for SUPPORT.  N Engl J Med.  2015 Oct 8;373(15):1469-1470.  Epub 2015 Sep 2.  PubMed PMID: 26332278.
http://www.ncbi.nlm.nih.gov/pubmed/26332278

3.  Drazen JM, Solomon CG, Greene MF.  Informed consent and SUPPORT.  N Engl J Med.  2013 May 16;368(20):1929-31. doi: 10.1056/NEJMe1304996.  Epub 2013 Apr 17.
PubMed PMID: 23593944.  http://www.ncbi.nlm.nih.gov/pubmed/23593944

Optional reading:
1.  SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network.  Target ranges of oxygen saturation in extremely preterm infants.  N Engl J Med.  2010 May 27;362(21):1959-69. doi: 10.1056/NEJMoa0911781.  Epub 2010 May 16. 
PubMed PMID: 20472937.  http://www.ncbi.nlm.nih.gov/pubmed/20472937

2.  Public Citizen.  Public Citizen: Oxygen Experiment On Premature Babies Is Highly Unethical.  Health Letter. 
2013 June;26:6  http://www.citizen.org/Page.aspx?pid=5971

3.  Buchanan LR.  The Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT).  OHRP. 
2013 March 7.  http://www.hhs.gov/ohrp/detrm_letrs/YR13/mar13a.pdf

November 19, 2015
E9519






 
Required reading:
1.  Wise RA, Bartlett SJ, Brown ED, et al. Randomized trial of the effect of drug presentation on asthma outcomes: the American Lung Association Asthma Clinical Research Centers. J Allergy Clin Immunol. 2009 Sep;124(3):436-44, 444e1-8. doi: 10.1016/j.jaci.2009.05.041. PubMed PMID: 19632710.
http://www.ncbi.nlm.nih.gov/pubmed/19632710

Optional reading:
1.  Clerisme-Beaty EM, Bartlett SJ, Teague WG, et al. The Madison Avenue effect: how drug presentation style Influences adherence and outcome in patients with asthma. J Allergy Clin Immunol. 2011 Feb;127(2):406-11. doi: 10.1016/j.jaci.2010.11.038. PubMed PMID: 21281871
http://www.ncbi.nlm.nih.gov/pubmed/21281871

December 17, 2015
E6519







 

Required readings:
1.  ​Derogatis LR, Komer L, Katz M, Moreau M, Kimura T, Garcia M, Jr., et al. Treatment of hypoactive sexual desire disorder in premenopausal women: Efficacy of flibanserin in the VIOLET Study. The Journal of Sexual Medicine.
2012 Apr;9(4):1074-85.
http://www.ncbi.nlm.nih.gov/pubmed/22248038


2.  Gellad WF, Flynn KE, Alexander GC. Evaluation of Flibanserin: Science and Advocacy at the FDA. JAMA.
2015 Sep 1;314(9):869-70.
http://www.ncbi.nlm.nih.gov/pubmed/26148201

Optional reading:
1.  Approval Letter.
http://www.accessdata.fda.gov/drugsatfda_docs/appletter/2015/022526ltr.pdf

February 18, 2016
W3011

 

Required reading:
1.  The SPRINT Research Group; Wright JT, Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM et al.  A randomized trial of intensive versus standard blood-pressure control.  N Engl J Med. 2015;373:2103-16. 
http://www.ncbi.nlm.nih.gov/pubmed/26551272

2.  Perkovic  V and Rodgers A.  Redefining blood-pressure targets -- SPRINT starts the marathon.  N Engl J Med. 2015;373:2175-78. 
http://www.ncbi.nlm.nih.gov/pubmed/26551394

Optional reading:
1.  Chobanian AV.  Time to reassess blood-pressure goals.  N Engl J Med.  2015;373(22):2093-95.
http://www.ncbi.nlm.nih.gov/pubmed/8096582


 
March 24, 2016
E9519

 

Required reading:
1.  Weinstein JN, Tosteson TD, Lurie JD, Tosteson AN, Hanscom B, Skinner JS, et al.  Surgical vs nonoperative treatment for lumbar disk herniation:  The Spine Patient Outcomes Research Trial (SPORT):  A randomized trial.  JAMA. 2006 Nov 22;296(20):2441-50. 
http://www.ncbi.nlm.nih.gov/pubmed/17119140

Optional reading:
1.  Weinstein JN, Lurie JD, Tosteson TD, Skinner JS, Hanscom B, Tosteson AN, et al.  Surgical vs nonoperative treatment for lumbar disk herniation:  The Spine Patient Outcomes Research Trial (SPORT) observational cohort.  JAMA.  2006 Nov 22;296(20):2451-59.
http://www.ncbi.nlm.nih.gov/pubmed/17119141


 

April 21, 2016
W2029

 

Required reading:
1.  Rugg-Gunn AJ, Spencer AJ, Whelton HP, et al.  Critique of the review of "Water fluoridation for the prevention of dental caries" published by the Cochrane Collaboration in 2015.  Br Dent J.  2016 Apr 8;220(7):335-40.
http://www.ncbi.nlm.nih.gov/pubmed/27056513

Optional reading:
1.  Iheozor-Ejiofor Z, Worthington HV, Walsh T, et al.  Water fluoridation for the prevention of dental cariesCochrane Database Syst Rev.  2015 Jun 18;6:CD010856.
http://www.ncbi.nlm.nih.gov/pubmed/26092033

2. Bonell C, Fletcher A, Morton M, et al.  Realist randomised controlled trials: a new approach to evaluating complex public health interventions.  Soc Sci Med 2012 Dec;75(12):2299-306.
http://www.ncbi.nlm.nih.gov/pubmed/22989491

 

May 12, 2016
E6519

 

Required reading:
1.  Du Toit G, Roberts G, Sayre PH, et al.  Randomized trial of peanut consumption in infants at risk for peanut allergy.  N Engl J Med.  2015 Feb 26;372(9):803-13.
http://www.ncbi.nlm.nih.gov/pubmed/25705822

Optional reading:
1.  Du Toit G, Sayre PH, Roberts G, et al.  Effect of Avoidance on Peanut Allergy after Early Peanut Consumption. 
N Engl J Med.  2016 Apr 14;374(15):1435-43
.
http://www.ncbi.nlm.nih.gov/pubmed/26942922

Information from past years:
 

Academic YearLink
2014-20152014-2015 Journal Club schedule (PDF)
2013-2014
 
2013-2014 Journal Club schedule (PDF)
2013-2014 Journal Club schedule (HTML)
2012-20132012-2013 Journal Club schedule (PDF)
2011-20122011-2012 Journal Club schedule (PDF)
2010-20112010-2011 Journal Club schedule (PDF)
2009-20102009-2010 Journal Club schedule (PDF)
2008-20092008-2009 Journal Club schedule (PDF)
 

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