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Center for Immunization Research

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RSV Selected Publications

Karron RA, Thumar B, Schappell E, Buchholz UJ, Collins PL. Attenuation of live respiratory syncytial virus vaccines is associated with reductions in levels of nasal cytokines. J Infect Dis 2013Jun 1;207(11):1773-9 

Karron RA, Buchholz UJ, Collins PL. Live-attenuated respiratory syncytial virus vaccines. Curr Top Microbiol Immunol. 2013;372:259-84.

Shinoff JJ, O'Brien KL, Thumar B, Shaw JB, Reid R, Hua W, Santosham M, Karron RA. Young infants can develop protective levels of neutralizing antibody after infection with respiratory syncytial virus. J Infect Dis. 2008 Oct 1;198(7):1007-15.

Eick A, Karron R, Shaw J, Thumar B, Reid R, Santosham M, O'Brien KL. The role of neutralizing antibodies in protection of American Indian infants against respiratory syncytial virus disease. Pediatr Infect Dis J  2008; 27(3):207-12.Wright PF, Karron RA, Belshe RB, Shi JR, Randolph VB  Collins PL, O'Shea AF, Gruber WC, Murphy BR. The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines. Vaccine. 2007; 25(42):7372-8.

Melendi GA, Hoffman SJ, Karron RA, Irusta PM, Laham FR, Humbles A, Schofield B, Pan CH, Rabold R, Thumar B, Thumar A, Gerard NP, Mitzner W, Barnum SR, Gerard C, Kleeberger SR, Polack FP. C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression. J Virol 2007 Jan;81(2):991-9. Epub 2006 Nov 1 .

Klein MI, Coviello S, Bauer G, Benitez A, Serra ME, Schiatti MP, Delgado MF, Melendi GA, Novalli L, Pena HG, Karron RA, Kleeberger SR, Polack FP. The impact of infection with human metapneumovirus and other respiratory viruses in young infants and children at high risk for severe pulmonary disease. J Infect Dis. 2006 Jun 1;193(11):1544-51.

Wright PF, Karron RA,  Madhi SA, Treanor JJ,  King JC, O’Shea A, Ikizler MR, Zhu Y, Collins PL, Cutland C, Randolph VB, Deatly AM, Hackell JG, Gruber WC, Murphy BR.  The interferon antagonist NS2 protein of respiratory syncytial virus is an important virulence determinant for humans.  J Infect Dis . 2006 Feb 15; 193(4):573-81.

Polack FP, Irusta PM, Hoffman SJ, Schiatti MP, Melendi GA, Delgado MF, Laham FR, Thumar B, Hendry RM, Melero JA, Karron RA, Collins PL, Kleeberger SR. The cysteine-rich region of respiratory syncytial virus attachment protein inhibits innate immunity elicited by the virus and endotoxin. Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8996-9001

Karron RA, Wright PF, Belshe RB, Thumar B, Casey R, Newman F, Polack FP, Randolph VB, Deatly A, Hackell J, Gruber W, Murphy BR, Collins PL.  Identification of a recombinant live attenuated respiratory syncytial virus vaccine candidate that is highly attenuated in infants. J Infect Dis  2005 Apr 1;191(7):1093-104.

Belshe RB, Newman FK, Anderson EL, Wright PF, Karron RA, Tollefson S, Henderson FW, Meissner HC, Madhi S, Roberton D, Marshall H, Loh R, Sly P, Murphy B, Tatem JM, Randolph V, Hackell J, Gruber W, Tsai TF.  Evaluation of combined live, attenuated respiratory syncytial virus and parainfluenza 3 virus vaccines in infants and young children.  J Infect Dis. 2004 Dec 15;190(12):2096-103.

Harcourt JL, Karron RA, Tripp RA. Anti-G protein antibody responses to respiratory syncytial virus infection or vaccination are associated with inhibition of G protein CX3C-CX3CR1 binding and  leukocyte chemotaxis. J Infect Dis . 2004 Dec 1(11); 190:1936-40.

Polack FP, Karron RA. The future of respiratory syncytial virus vaccine development.  Pediatr Infect Dis J. 2004 Jan;23(1 Suppl):S65-73.

Durbin AP, Karron RA. Progress in the development of respiratory syncytial virus and parainfluenza virus vaccines.  Clin Infect Dis. 2003 Dec 15;37(12):1668-77. Epub 2003 Nov 20.

Polack FP, Teng M, Kleeberger S, Hoffman SJ, Collins P, Wills-Karp M, Prince G, Karron RA. A role for immune complexes in enhanced respiratory syncytial virus disease.J Exp Med. 2002;196:859-65.

Wright PF, Karron R, Belshe RB, Thompson J, Crowe JE, Boyce TG, Halburnt LL, Reed GW,Whitehead SS, Anderson EA, Wittek AC, Casey R, Eichelberger M, Thumar B, Randolph VB,Udem SA, Murphy BR. Evaluation of a Live, Cold-Passaged, Temperature-Sensitive, Respiratory Syncytial Virus (RSV) Vaccine in Infancy. J Infect Dis 2000; 182(5):1331-1342.

Gonzalez IM, Karron RA, Eichelberger M, Walsh EE, Delagarza VW, Bennett R, Chanock RM, Murphy BR, Clements-Mann ML, Falsey AR. Evaluation of the live attenuated cpts248/404 RSV vaccine in combination with a subunit RSV vaccine (PFP-2) in healthy young and older adults. Vaccine . 2000; 18:1763-1722.

Karron RA, Singleton RJ, Bulkow L, Parkinson A, Kruse D, DeSmet I, Indorf C, Petersen KM, Leombruno D, Hurlburt D, Santosham M, Harrison LH, for the RSV Alaska Study Group. Severe respiratory syncytial virus disease in Alaska Native Children. J Infect Dis . 1999; 180 (1):41-9.

Dudas RA, Karron RA.  Respiratory syncytial virus vaccines.  Clin Microbiol Rev. 1998 Jul;11(3):430-9

Karron RA, Buonagurio DA, Georgiu AF, Whitehead SS, Adamus JE, Clements-Mann ML, Harris DO, Randolph VB, Udem SA, Murphy BR, Sidhu MS. Respiratory syncytial virus SH and G proteins are not essential for viral replication in vitro clinical evaluation and molecular characterization of a cold-passaged, attenuated RSV subgroup B mutant.Proc Natl Acad Sci. 1997 Dec 9; 94:13961-66.

Karron RA, Wright PF, Crowe JE Jr, Clements ML, Thompson J, Makhene M, Casey R, Murphy BR. Evaluation of two live, cold-passaged, temperature-sensitive respiratory syncytial virus (RSV) vaccines in chimpanzees, adults, infants and children. J Infect Dis . 1997 Dec 176:1428-37.