Skip Navigation
Center for Human Nutrition

 

Richard Semba

Professor
Academic Degrees
B.S., Yale University 1978; M.A., Stanford University 1983; M.D., Stanford University 1983; M.P.H., Johns Hopkins University 1991.
Departmental Affiliation
Ophthalmology
Joint Departmental Affiliations
International Health; Molecular Microbiology and Immunology
Departmental Address
Smith Building, M015, 400 N Broadway
Baltimore, MD 21287
Phone: 410-955-3572
Fax: 410-502-1753
Research and Professional Experience

 

Dr. Semba is the inaugural W. Richard Green Professor of Ophthalmology at the Wilmer Eye Institute. He holds joint appointments in the Department of Molecular Microbiology and Immunology and the Department of International Health. Dr. Semba received his B.S. from Yale University (1978), M.A. and M.D. from Stanford University (1983), and M.P.H. from Johns Hopkins University (1991). He completed his ophthalmology residency at the Wilmer Eye Institute. Dr. Semba has been a faculty member at Johns Hopkins University since 1987. 

Dr. Semba’s areas of research include the characterization of emerging biomarkers for adverse aging-related outcomes and the application of proteomics and mass spectrometry to the understanding of chronic diseases.

Dr. Semba has over three hundred peer-reviewed scientific publications. He is the author of three books: “Handbook of Nutrition and Ophthalmology” (Humana Press, 2007), "The Vitamin A Story: Lifting the Shadow of Death" (Karger, 2012), and (with co-author Kristine Smets) "A Perfect Vision: Catalogue of the William Holland Wilmer Rare Book Collection" (Johns Hopkins, 2013). Dr. Semba is co-editor (with Martin Bloem) of the widely used textbook “Nutrition and Health in Developing Countries” (Humana Press, first edition, 2001; second edition, 2008).

Keywords

aging; age-related macular degeneration; diabetes; diabetic retinopathy; eye diseases; proteins; proteomics; mass spectrometry; metabolomics; lipidomics; sarcopenia; systems biology; vitamin A; vitamins

Honors and Awards

Lew R. Wasserman Merit Award from Research to Prevent Blindness (2006)

W. Richard Green Professor of Ophthalmology (2007-present)

Selected Publications

2012

Semba RD, Sun K, Cappola AR, Fink JC, Dalal M, Crasto C, Ferrucci L, Fried LP. Elevated serum fibroblast growth factor 23 predicts incident chronic kidney disease in older community-dwelling women. Clin J Am Soc Nephrol 2012; 7: 85-91.

Semba RD. The historical evolution of thought regarding multiple micronutrient nutrition. J Nutr 2012; 142: 143S-156S.

Semba RD, Sun K, Egan JM, Crasto C, Carlson OD, Ferrucci L. Elevated serum fibroblast growth factor 21 is associated with abnormal glucose metabolism and insulin resistance: the Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab 2012; Feb 16 [Epub ahead of print].

2011

Semba RD, Kraemer K, Sun K, de Pee S, Akhter N, Moench-Pfanner R, Rah JH, Campbell AA, Badham J, Bloem MW. Relationship of latrine use with diarrhea and under-five child mortality in Indonesia. Am J Trop Med Hyg 2011; 84: 443-450.

Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L. Plasma klotho and mortality risk in older community-dwelling adults. J Gerontol A Biol Sci Med Sci 2011; 66: 794-800.

Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L. Plasma klotho and cardiovascular disease in adults. J Am Geriatr Soc 2011; 59: 1596-1601.

Semba RD, Cappola AR, Sun K, Bandinelli S, Dalal M, Crasto C, Guralnik JM, Ferrucci L. Relationship of low plasma klotho with grip strength in older community dwelling adults: the InCHIANTI Study. Eur J Appl Physiol 2011; July 17 [Epub ahead of print].

Semba RD, Ang A, Talegawkar C, Crasto C, Dalal M, Jardack P, Traber MG, Ferrucci L, Arab L. Dietary intake of serum versus urinary carboxymethyl-lysine, a major advanced glycation end product, in adults: the Energetics Study. Eur J Clin Nutr 2011; July 27 [Epub ahead of print].

Semba RD, Arab L, Sun K, Nicklett EJ, Ferrucci L. Fat mass is inversely associated with serum carboxymethyl-lysine, an advanced glycation end product, in adults. J Nutr 2011; 141: 1726-1730.

Dalal M, Sun K, Cappola AR, Ferrucci L, Crasto C, Fried LP, Semba RD. Relationship of serum fibroblast growth factor 23 with cardiovascular disease in older community-dwelling women. Eur J Endocrinol 2011; 165: 797-803.

2010

Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin and anemia in older persons. Blood 2010; 115: 3810-3816.

Semba RD, Moench-Pfanner R, Sun K, de Pee S, Akhter N, Rah JH, Campbell AA, Badham J, Bloem MW, Kraemer K. Iron-fortified milk and noodle consumption are associated with lower risk of anemia among children, aged 6-59 months, in Indonesia. Am J Clin Nutr 2010; 92: 170-176.

Tanaka T, Roy C, Yao W, Matteini A, Semba RD, Arking D, Walston JD, Fried LP, Singleton A, Guralnik J, Abecasis GR, Bandinelli S, Longo DL, Ferrucci L. A genome-wide association analysis of serum iron concentrations. Blood 2010; 115: 94-96.

Semba RD, de Pee S, Sun K, Raju VK. The role of expanded coverage of the national vitamin A program in preventing morbidity, mortality, and blindness among preschool children in India. J Nutr 2010; 140: 208S-212S.

2009

Ferrucci L, Perry JRB, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried L, Albanes D, Corsi AM, Guralnik J, Bandinelli S, Singleton A, Virtamo J, Walston J, Semba RD, Frayling TM. Common variation in the β-carotenoid 15,15’- monooxygenase gene affects circulating levels of carotenoids: a genome wide association study. Am J Hum Genetics 2009; 84: 123-133.

Semba RD, Ferrucci L, Fink JC, Sun K, Beck J, Dalal M, Guralnik JM, Fried LP. Elevated serum advanced glycation end products and their circulating receptors are associated with renal insufficiency in a cohort of older community-dwelling women. Am J Kidney Dis 2009; 53: 51-58.

Semba RD, Najjar S, Sun K, Lakatta EG, Ferrucci L. Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults. Am J Hypertens 2009; 26: 74-79.

Bandeen-Roche K, Walston JD, Huang Y, Semba RD, Ferrucci L. Measuring systemic inflammatory regulation in older adults: evidence and utility. Rejuvenation Res 2009; 12: 403-410.

2008

Semba RD, de Pee S, Sun K, Sari M, Akhter N, Bloem MW. Effect of parental formal education on risk of child stunting in Indonesia and Bangladesh: a cross-sectional study. Lancet 2008; 371: 322-328.

Semba RD, de Pee S, Sun K, Best C, Sari Y, Bloem MW. Paternal smoking and increased risk of infant and under-five child mortality among families in Indonesia. Am J Public Health 2008; 98: 1824-1826.