Dr. Holbrook is an Associate Professor of Epidemiology at the Johns Hopkins Univeristy Bloomberg School of Public Health. She has over twenty years of experience in the design and conduct of multicenter studies, particularly randomized clinical trials. Currently, Dr. Holbrook serves as the Director of the Coordinating Center for the Multicenter Uveitis Steroid Treatment Trial (MUST) and for the Trial of CPAP for Asthma (CPAP). MUST is a multicenter randomized comparative effectiveness trial comparing an intraocular fluocinolone acetonide intravitreous implant versus systemic treatment for non-infectious uveitis. The trial enrolled 255 patients at 23 centers, 21 in the United States and one each in the United Kingdom and Australia, and reached the designed primary outcome (visual acuity at 2 years) in December 2010. Since uveitis is a chronic disease, questions concerning the long-term outcomes are of interest. The NEI has funded the MUST Research Group to continue follow-up on all participants for 7 years. The CPAP trial is a multicenter phase 2 trial, involving 18 clinic centers in the Asthma Clinical Research Centers (ACRC) network. The objective of the trial is to evaluate the efficacy and tolerability of CPAP for treatment of asthma in 192 subjects.
The ACRC network was funded by the American Lung Association (ALA) in 1999 with the mission to conduct research that has a direct impact on clinical care. The Network has leveraged the ALA funding of the core infrastructure to obtain grant funding from NIH and the pharmaceutical industry. Dr. Holbrook has served as the deputy director of the ALA-ACRC Data Coordinating Center since it was founded. The ACRC Network has completed the 7 randomized clinical trials, is finishing follow-up in 2 trials and has 2 trials open for recruitment. The completed trials have enrolled between 300 and 2,000 participants and all have been published in high impact journals. The network is considered a model for the conduct of multicenter randomized trials that address clinically meaningful questions. Dr. Holbrook teaches a course on the design, conduct and interpretation of clinical trials at the Bloomberg School of Public Health and for the FDA Commissioner’s Fellowship Program.
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