PROJECT 3         BIOLOGICAL AND TOXICOLOGICAL ASSESSMENT

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Bill Spannhake, PhD
Environmental Health Sciences
Director

Dr. Spannhake has considerable experience in airway epithelium and the effect of environmental pollutants such as ozone on airway inflammation. He is working closely with the animal models and bioassay lab in Chicago under Dr. Garcia.

Environmental Health Sciences
Lab Assistant

SUBAWARD:        UNIVERSITY OF CHICAGO, SCHOOL OF MEDICINE

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Joe G.N. Garcia MD
Professor & Chair
Director

Dr. Garcia’s expertise includes endothelial biology, vascular injury, genomics and proteomics; he oversees the Chicago-based lab and direction of the research. His experience in endothelial barrier regulation and pulmonary edema is very critical in understanding the role of particulate matter in causing lung injury in murine models as well as human studies. His expertise in genomics is advancing the development of particulate matter-induced toxicogenomics.
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Vishwanathan Natarajan, PhD
Professor
Co-Investigator

Dr. Natarajan’s expertise includes lipidomics, cell signaling, oxidant-induced endothelial barrier dysfunction, biomarkers in acute lung injury and airway biology/inflammation. He is responsible for carrying out studies related to signaling pathways regulating particulate matter-mediated secretion of cytokines/chemokines in human bronchial epithelial cells. Additionally, he oversees the day-to-day operation of the project and supervises all the research personnel involved in the in vivo and in vitro studies.
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Liliana Moreno, PhD
Assistant Professor
Co-Investigator

Dr. Moreno's main interest is to find new and effective intervention strategies for cardiopulmonary disorders such as acute lung injury and pulmonary hypertension by developing small animal models of disease.  She is involved in studies related to particulate matter exposure of murine models and lung injury.
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Eric Svensson, PhD, MD
Assistant Professor
Co-Investigator

Dr. Svensson is interested in the molecular basis for congenital heart disease. His research is focused on understanding the transcriptional regulation of cardiac development and identifying novel genes critical for the formation of the heart.  He has extensive experience in murine models of cardiac dysfunction.

   

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