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April 23, 2015

BPA Risk to Newborns May Be Smaller Than Previously Believed

Study of days-old infants shows innate ability to clear controversial compound used in plastics from the body

 

Johns Hopkins Bloomberg School of Public Health researchers say that while a large majority of newborns are exposed in their earliest days to bisphenol A (BPA), a much-studied chemical used in plastics and in food and soda can linings, they can chemically alter and rid their bodies of it.

The findings, published April 23 in The Journal of Pediatrics, challenge the current thinking on BPA toxicology. The U.S. Centers for Disease Control and Prevention has found that more than 92 percent of Americans ages 6 and older have BPA in their bodies, most likely through the consumption of food stored in packaging made from it. No one had studied levels in healthy newborns, but it was assumed that their immature livers would have a difficult time processing the chemical and that could mean increased health risks due to BPA.

BPA mimics the sex hormone estrogen in the body and may have developmental effects on the brain, lung and reproductive organs, and has been associated with diabetes and some cancers. It is currently used in many plastics in the United States, but was banned in baby bottles and sippy cups in 2012 by the Food and Drug Administration for fear of what the chemical could do to the very young. But BPA is still in wide use because the FDA has repeatedly concluded that it is safe at the current levels occurring in foods.

“Even though we’ve removed BPA from bottles, this work shows infants are still exposed to it,” says study leader Rebecca Massa Nachman, PhD, MPH, a post-doctoral fellow in the Johns Hopkins Bloomberg School of Public Health’s Department of Environmental Health Sciences. “But the good news is that our study also shows healthy newborns are better able to handle that exposure than we thought."

For their study, conducted between December 2012 and August 2013, Nachman and her colleagues collected urine samples from 44 full-term babies, once between 3 and 6 days of age and again between 7 and 27 days of age. They were looking for two forms of BPA: free BPA and BPA glucuronide. Free BPA is the chemical as it appears in consumer products, and BPA glucuronide is what remains after free BPA is metabolized by the body. The researchers found no free BPA in the urine samples, while more than 70 percent of the samples contained BPA glucuronide. BPA glucuronide is biologically inert and therefore considered harmless to the body.

Scientists were concerned that BPA would behave similarly in the body to bilirubin, a biological byproduct created by the breakdown of red blood cells. Healthy livers turn bilirubin into bilirubin glucuronide, a very similar process to the one BPA follows, which can then be excreted. Routinely, babies may have trouble with this process in their earliest days, resulting in jaundice in most newborns.

Nachman says researchers still don’t know how the babies were exposed to BPA. Notably, Nachman’s group found no difference between BPA glucuronide levels in infants who were formula fed and those who were breastfed. Fifty-one percent of the babies were fed formula exclusively, 28 percent were only fed breast milk and 21 percent consumed a combination of the two.

Studies have shown that powdered baby formula contains no BPA, while breast milk does. Among children and adults, food is believed to be the primary source of BPA found in the body, even though it is also found in cash register receipts, refillable water bottles, the lining of water pipes and even in dust.

Because of its short half-life, BPA found in the urine reflects recent contact with a source of BPA, making in-utero transmission from mother to baby an unlikely culprit.

“It must come from somewhere outside of the diet,” she says.

Urinary Free Bisphenol A and Bisphenol A Glucuronide Concentrations in Neonates in Baltimore, Maryland” was written by Rebecca M Nachman, PhD, MPH; Stephen D Fox, BS; William C Golden, MD; Erica Sibinga, MD, MHS; John D Groopman, PhD and Peter S Lees, PhD

This study was supported in part by the Johns Hopkins Center for a Livable Future-Lerner Fellowship, the Wendy Klag Memorial Fund, and by grants from the National Institutes of Health’s National Institute of Environmental Health Sciences (P01 ES006052, P30 ES003819 and training grant T32 ES007141) and the National Cancer Institute (P30 CA006973 and contract N01-CO-12400).

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Media contacts for the Johns Hopkins Bloomberg School of Public Health: Stephanie Desmon at 410-955-7619 or sdesmon1@jhu.edu and Barbara Benham at 410-614-6029 or bbenham1@jhu.edu.