This 66,000 child year trial in Southern Nepal assessed the efficacy of 10 mg zinc with or without 12.5 mg of iron and 50 ug of folic acid in reducing preschool child mortality and morbidity and improving growth, motor skills, and cognitive development. The trial received primary funding from the National Institutes of Health and the Bill and Melinda Gates Foundation. This study was a randomized, placebo controlled, community-based clinical trial. The iron-folic acid arms stopped in November 2003 to accelerate accrual of data on survival effects of zinc (zinc-placebo arms continued through January 2006). The first major paper on effects of iron and folic acid were published in the Lancet in January 2006. Principal Investigator: James Tielsch (JHSPH) JHSPH Co-Investigators: Nepal Nutrition Intervention Project (NNIPS) Co-Investigators: - Subarna Khatry
- Ramesh Adhikari
Publications: Siegel EH, Stoltzfus RJ, Kariger PK, Katz J, Khatry SK, LeClerq S, Pollitt E, Tielsch JM. Growth indicies, anemia, and diet independently predict motor milestone acquisition of infants in south central Nepal. J Nutr. 2005 Dec;135(12):2840-44. Siegel EH, Stoltzfus RJ, Khatry SK, LeClerq S, Katz J, Tielsch JM. Epidemiology of anemia among 4 to 17 month old children living in south central Nepal. European Journal of Clinical Nutrition. 2006 Feb;60(2):228-35. Tielsch, J., S . Khatry, R. Stoltzfus, J. Katz, S. LeClerq, R. Adhikari, L. Mullany, R. Black, S. Shresta. (2007). Effect of daily zinc supplementation on child mortality in southern Nepal: a community-based, cluster randomised, placebo-controlled trial. The Lancet, 370, 9594, 1230 - 1239. Tielsch JM, Khatry SK, Stoltzfus RJ, Katz J, LeClerq SC, Adhikari R, Mullany LC, Shresta S, Black RE. Effect of routine prophylactic supplementation with iron and folic acid on preschool child mortality in southern Nepal: Community-based, cluster-randomised, placebo-controlled trial. Lancet. 2006 Jan 14;367(9505):144-52. |
