Michael Trush, PhD
- Environmental Health and Engineering (Primary)
615 North Wolfe St., Rm E7537
Baltimore, Maryland 21205
PhD, West Virginia University, 1978
The overall goal of our research program was to investigate the interactions of environmental chemicals with leukocytes including polymorphonuclear leukocytes, mononuclear cells and their bone marrow progenitors. Disease endpoints of interest include aplastic anemia, agranulocytosis, leukemia and increased susceptibility to infections and cancer. Agents whose chemico-biological interactions are under investigation include benzene, polycyclic aromatic hydrocarbons, lead and agricultural chemicals. In this regard, our studies have focused in three areas: the bioactivation and molecular interactions of xenobiotics of interest; the biochemical and molecular regulation of myelopoiesis and cell differentiation; and the development of in vitro and in vivo models to provide a mechanistic basis for risk assessment and to develop chemoprotective strategies for myeloid cell toxicity. In order to accomplish the goals of the program we employ a spectrum of analytic, biochemical and molecular approaches including the use of chemilumigenic probing for which the laboratory is noted. This technology is based on the assessment of reactive oxygen by organells and cells. In this regard, our recent studies focus on the assessment and regulation of reactive oxygen by mitochondria.
From a translational environmental public health perspective, I am interested in the development and application of plant-derived nutraceuticals in environmental health and disease.
I am also interested in environmental public health education,from K-12 up to the community level .
Honors and Awards
2009,Environmental Justice Partnership, Award in Recognition of Addressing Environmental Health Concerns in Urban Communities;2006, Johns Hopkins Diversity Award; NIGMS Pharmacology Research Associate Fellowship ;CINE1996 award by the Council on Nontheatrical Events ;The New York Festivals 1996 Finalist Award ;Best paper in Toxicological Sciences, 2000. Outstanding Faculty Service Award from the Interaction Community Outreach Program, Bloomberg School of Public Health, 2004
- Environmental Health Sciences, environmental chemicals, reactive oxygen,mitochondria, benzene, benzo(a)pyrene, leukocytes, polymorphonuclear leukocytes, mononuclear cells, bone marrow progenitors, aplastic anemia, agranulocytosis, leukemia,Coutreach and engagement, K-12 education
The list below represents the most recent publications in accordance with my research interests .They are from a new journal, Reactive Oxygen Species, which was started by my former associate ,Dr. Y .Robert Li. Dr.Li is a Professor at Campbell University in North Carolina.
- H.Zhu ,K.Traore, ,A.Santo,MA Trush , and YR Li.Oxygen and oxygen toxicity: the birth of concepts. Reactive Oxygen Species . vol.1,pp1-8,2016.
- YR Li,Z Jia,and MA Trush. Defining ROS in biology and medicine .Reactive Oxygen Species. vol.1,pp 9-21,2016
- Y Li, H Zhu,P Kuppusamy,J Zweir and MA Trush. Mitochondrial electron transport chain-derived superoxide exits macrophages :implications for mononuclear cell -mediated pathophysiological processes. Reactive Oxygen Species,vol.1,pp.81-98,2016 .
- H Zhu, ME Kauffman, JZ Li,S Sarkar, MA Trush and YR Li. Innovative Bioluminometric Quantification of cancer cell load in target organs:implications for studying anticancer drugs,including ROS enhancers.Reactive Oxygen Species, vol.1,pp157-164, 2016.
- H Zhu, Z Jia, MA Trush and YR Li. A highly sensitive chemiluminometric assay for real-time detection of biological hydrogen peroxide formation. Reactive Oxygen Species,vol.1, pp.216-227,2016 .