David Sack, MD
- Division: Global Disease Epidemiology and Control
- Epidemiology (Joint)
Center & Institute Affiliations
615 N. Wolfe Street
Baltimore, Maryland 21205
MD, University of Oregon, 1969
My research has been focused on enteric infections and vaccine development for these infections.
With regard to enteric infections, this has included laboratory detection of these agents, describing their epidemiology in travelers and developing country populations, developing appropriate clinical management strategies including antibiotics and rehydration methods.
With regard to vaccines, I have participated in the development of vaccines for cholera, rotavirus, enterotoxigenic E coli, shigellosis and other bacterial infections.
Most recently, i have initiated a large project called the DOVE project (Delivering Oral Cholera Vaccine Effectively). Working in collaboration with UNICEF, WHO and other partners, this project will facilitate the use oral cholera vaccine as part of an integrated strategy for cholera control. A web site providing details on the use of oral cholera vaccine is at www.stopcholera.org
Honors and Awards
Gates Award for Global Health for the ICDDRB
Independence Day Award for the ICDDRB
- International Health
- cholera vaccine
- Gates Award
- enterotoxigenic Escherichia coli
- International Center
- oral rehydration solution
Selected publications from last 4 years.
- Ruan X, Sack DA, Zhang W. Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity. PLoS One 2015; 10(3): e0121623
- Ali M, Nelson AR, Lopez AL, Sack DA. Updated global burden of cholera in endemic countries. PLoS Negl Trop Dis 2015;9:e0003832.
- Debes AK, Ateudjieu J, Guenou E, Ebile W, Sonkoua IT, Njimbia AC, Steinwald P, Ram M, Sack DA, 2016. Clinical and Environmental Surveillance for Vibrio cholerae in Resource Constrained Areas: Application During a 1-Year Surveillance in the Far North Region of Cameroon. Am J Trop Med Hyg 94: 537-43.
- Sack, DA. A new era in the history of cholera: the road to elimination. International Journal of Epidemiology 2013;42:1537–1540.
- George CM, Monira S, Sack DA, Rashid MU, Saif-Ur-Rahman KM, Mahmud T, et al. Randomized Controlled Trial of Hospital-Based Hygiene and Water Treatment Intervention (CHoBI7) to Reduce Cholera. Emerg Infect Dis. 2016;22(2):233-41.