Marsha Wills-Karp, PhD
- Chair, Department of Environmental Health Sciences
615 N. Wolfe Street
Baltimore, Maryland 21205
PhD, University of California, Santa Barbara, 1986
MS, Southwest Texas State University, 1982
My research activities focus on defining the environmental and genetic determinants of allergic airway diseases such as asthma. My lab members and I have specifically explored the role of CD4+ Th2 cells and cytokines (IL-13), and innate immune pathways (complement activation pathways, TLRs, CLRs), in the pathogenesis of asthma. I have made substantial contributions to our understanding of the molecular mechanisms underlying allergenicity of common allergens-specifically how allergens and airborne pollutants activate innate immune pathways through molecular mimicry (Nature). More recently, I have turned my attention to how the gut microbiome alters susceptibility to allergen and PM-induced asthma.
Honors and Awards
Delta Omega Public Health Honor Society, 2014
Rebecca Buckley Lectureship (2012)
Chair of NIH AITRC Study Section (2011 - present) Permanent Member NIH AITRC Study Section (2009 - present) Fellow of Pediatric Society (2009 - present) Associate Editor, Mucosal Immunity, (2007 - present) John Salvaggio Memorial Lectureship (2001) Permanent Member, National Institutes of Health Study Section-Lung Biology and Pathology (2000 - 2004) Sigma Xi - The Scientific Research Society (1980 - present) Tri-Beta Biological Honor Society (1979 - 1982) Faculty of 1000
- Allergy, Asthma, Immunology, Pulmonary Biology, Environmental Health, Air Pollution, Genetics of Asthma, Microbiome
Asthma is one of the most common chronic disorders in childhood.
Listed are 5 out of 147 publications
- Wills-Karp M, Rani R, Dienger K, Fox J, Perkins C, Finkelman FD, Smith DE, Curt-Jones EA, Wang T, Sivaprasad U, Hershey GK, Herbert DR. Trefoil factor 2 rapidly induces interleukin 33 to promote type 2 immunity during allergic asthma and hookworm infection. J. Exp. Med. 209(3):607-22, 2012. PMC:330222