Thomas Sussan, PhD
615 N. Wolfe Street, Room E7035
Baltimore , Maryland 21205
PhD , Johns Hopkins School of Medicine , 2006
I am interested in how various environmental exposures (ie. cigarette smoke, indoor/outdoor air pollution, allergens, bacteria, and viruses) result in respiratory respiratory diseases, such as COPD, asthma, and innate immune dysfunction. We are interested in identifying biochemical pathways that alter susceptibility to disease, through genetically modified animal models and pharmacological agents.
Honors and Awards
2012- Household Air Pollution Training Institute participant, National Center for Global Health Studies at the NIH Fogarty International Center.
2011- Chairperson- “Epigenetics in Toxicology: Introduction, Mechanistic Understanding, and Applications in Safety Assessment.” Society of Toxicology, Continuing Education Course. Washington, DC.
2010- Flight Attendants Medical Research Institute (FAMRI) Young Clinical Scientist Award
2006-2009 National Institute of Environmental Health Sciences Training Award [T32]
2005 Teaching Assistant in “Mammalian Genetics”, in graduate course Fundamentals of Genetics, Johns Hopkins School of Medicine, Baltimore, MD
2003 Summer Institute in Statistical Genetics, North Carolina State University, Raleigh, NC
2001 Travel Award for the short course on “Experimental Genetics of the Laboratory Mouse in Cancer Research”, Jackson Laboratory, Bar Harbor, ME
Cigarette smoke, biomass, household air pollution, oxidative stress, inflammation,asthma
Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS Jr. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo1 expression. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L615-22.
Alder JK, Guo N, Kembou F, Parry EM, Anderson CJ, Gorgy AI, Walsh MF, Sussan T, Biswal S, Mitzner W, Tuder RM, Armanios M. Telomere Length is a Determinant of Emphysema Susceptibility. Am J Respir Crit Care Med. 2011 Jul 14.
Yoshida T, Mett I, Bhunia AK, Bowman J, Perez M, Zhang L, Gandjeva A, Zhen L, Chukwueke U, Mao T, Richter A, Brown E, Ashush H, Notkin N, Gelfand A, Thimmulappa RK, Rangasamy T, Sussan T, Cosgrove G, Mouded M, Shapiro SD, Petrache I, Biswal S, Feinstein E, Tuder RM. (2010). Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke-induced pulmonary injury and emphysema. Nat Med. 2010 Jul;16(7):767-73.
Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, Tuder R, Biswal S. (2009). Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. Am J Respir Crit Care Med. 180(12):1196-207.
Hill CA, Sussan TE, Reeves RH, Richtsmeier JT. (2009). Complex contributions of Ets2 to craniofacial and thymus phenotypes of trisomic "Down syndrome" mice. Am J Med Genet A. 149A(10):2158-65.