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Fengyi Wan, PhD

Oncology

Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

Assistant Professor

Departmental Affiliation(s):

Biochemistry and Molecular Biology
School of Medicine (Joint)

Contact Information

615 North Wolfe Street, W8025
Baltimore , Maryland   21205
US        

(410) 955-5848
(410) 955-2926

Education

PhD , Chinese Academy of Sciences , 2003

Overview

Research in our laboratory focuses on the regulatory specificity of NF-κB. NF-κB is a pleiotropic transcription factor that involves with diverse biological activities, and aberrant NF-κB signaling has been recognized to associate with variety of diseases including cancer and inflammatory diseases; however, the regulatory specificity of NF-κB remains one of the most important yet unresolved questions. Our recent work demonstrated that NF-κB DNA binding activity could be regulated within NF-κB complexes through synergistic interaction between Rel and non-Rel subunits, thus shedding new insights into the specificity. We are studying the molecular mechanism and the pathophysiological significance of these non-Rel subunits-conferred regulatory specificity of NF-κB in pathogen infection, inflammation, and tumorigenesis, with a combination of biochemical, molecular, cellular and genetic approaches.

Honors and Awards

Yong-Ling Liu Award, Chinese Academy of Sciences (2002)

Director Award, Chinese Academy of Sciences (2003)

Howard Temin Pathway to Independence Award in Cancer Research, NCI (2008)

AAI-Invitrogen Trainee Achievement Award, American Association of Immunologists (2009)

American Cancer Society Research Scholar, ACS (2013)

Signal transduction, gene regulation, transcription factor, protein-nucleic acid interaction, pathogen infection, inflammation, cancer.

  • K Fu*, X Sun*, W Zheng*, EM Wier, A Hodgson, DQ Tran, S Richard, & F Wan (2013) Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells. Nat. Commun. 4: 1909 * equal contribution

  • EM Wier, J Neighoff, X Sun, K Fu, & F Wan (2012) Identification of an N-terminal truncation of the NF-κB p65 subunit that specifically modulates ribosomal protein S3-dependent NF-κB gene expression. J. Biol. Chem. 287 (51): 43019-43029

  • K Fu, X Sun, W Zheng, EM Wier, A Hodgson, DQ Tran, S Richard, & F Wan (2013) Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells. Nat. Commun. 4: 1909

    F Wan, A Weaver, X Gao, M Bern, PR Hardwidge, & MJ Lenardo (2011) IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7. Nat. Immunol. 12 (4): 335-343

    F Wan, DE Anderson, RA Barnitz, A Snow, N Bidere, L Zheng, V Hegde, LT Lam, LM Staudt, D Levens, WA Deutsch & MJ Lenardo (2007) Ribosomal Protein S3: A KH Domain Subunit in NF-κB Complexes that Mediates Selective Gene Regulation. Cell 131(5): 927-939