Anthony K. L. Leung, PhD
Affiliate Member, Institute of McKusick-Nathans Genetic Medicine, Johns Hopkins School of Medicine
615 N. Wolfe Street
Baltimore , Maryland 21205
+1 (410) 955 2926
PhD , University of Dundee , 2003
MBioch , University of Oxford , 1999
Poly(ADP-ribose) Regulation of microRNA activities
My research program focuses on understanding the relationship between microRNAs and stress in cancers, using biochemical, cellular imaging and genomics approaches. Recently, we discovered that microRNA activity is regulated by poly(ADP-ribose), a "druggable" post-translational modification that is essential in multicellular organisms. Dysregulation in synthesis of poly(ADP-ribose) results in human diseases including cancers. My research program is to characterize how this post-translational affects the activities of RNA-mediated gene regulation and to test whether human diseases can be treated by inhibitors against poly(ADP-ribose) metabolism.
Honors and Awards
2011-2013 Idea Award, Department of Defense Breast Cancer Research Program
2007-2010 Special Fellowship, The Leukemia & Lymphoma Society
2004-2007 Long-term Fellowship, Human Frontier Science Program
Jul-Aug 2003 Travelling Fellowship, Journal of Cell Science, Company of Biologist Limited
Jun-Jul 2002 European Advanced Light Microscopy Facility Fellowship, EMBL Heidelberg, Germany
1999-2002 Scholarship, Croucher Foundation, Hong Kong
1999-2002 Overseas Research Scheme Award, UK
1995-1999 Waugh Scholarship, University of Oxford, UK
1995-1999 Fitzgerald Prize, University of Oxford, UK
Poly(ADP-ribose), microRNAs, Cancers, RNA regulation, RNA granules, stress responses, therapeutic siRNAs, high-resolution imaging, quantitative proteomics, bioinformatics
Daniels CM, Ong SE, Leung AK. Phosphoproteomic Approach to Characterize Protein Mono- and Poly(ADP-ribosyl)ation Sites from Cells. J Proteome Res. 2014 PMID: 24920161.
Leung AK. Poly(ADP-ribose): An organizer of cellular architecture. J Cell Biol. 2014 PMID: 24914234
Ando Y, Leung AK. Does an emergency visit to the ER make microRNAs stronger during stress? Mol Cell. 2013 PMID: 24119397.
Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol Cell. 2011 PMID: 21596313
Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat Struct Mol Biol. 2011 PMID: 21258322
Selected publications (5 out of 25); team members are underlined.