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Anthony K. L. Leung, PhD

Affiliate Member, Institute of McKusick-Nathans Genetic Medicine, Johns Hopkins School of Medicine

Assistant Professor

Departmental Affiliation(s):

Biochemistry and Molecular Biology

Contact Information

615 N. Wolfe Street, E8632, Baltimore, MD 21205
Baltimore , Maryland   21205

+1 (410) 502 8939
+1 (410) 955 2926

SciVal Experts Research Profile


PhD , 2003



My research program focuses on understanding the relationship between microRNAs and stress in cancers and mouse embryonic stem cells, using biochemical, cellular imaging and genomics approaches. Recently, I discovered that microRNA activity is regulated by poly(ADP-ribose), a "druggable" post-translational modification that is essential in multicellular organisms. Dysregulation in synthesis of poly(ADP-ribose) results in human diseases including cancers. My research program is to characterize how this post-translational affects the activities of RNA-mediated gene regulation and to test whether human diseases can be treated by inhibitors against poly(ADP-ribose) metabolism.



Honors and Awards

2011-2013 Idea Award, Department of Defense Breast Cancer Research Program

2007-2010 Special Fellowship, The Leukemia & Lymphoma Society

2004-2007 Long-term Fellowship, Human Frontier Science Program

Jul-Aug 2003 Travelling Fellowship, Journal of Cell Science, Company of Biologist Limited

Jun-Jul 2002 European Advanced Light Microscopy Facility Fellowship, EMBL Heidelberg, Germany

1999-2002 Scholarship, Croucher Foundation, Hong Kong

1999-2002 Overseas Research Scheme Award, UK

1995-1999 Waugh Scholarship, University of Oxford, UK

1995-1999 Fitzgerald Prize, University of Oxford, UK

Poly(ADP-ribose), microRNAs, Cancers, RNA regulation, RNA granules, stress responses, therapeutic siRNAs, high-resolution imaging, quantitative proteomics, bioinformatics


    Journal Articles


    1. Leung, A.K., Vyas, S., Rood, J.E., Bhutkar, A.J., Sharp, P.A. and Chang, P. Poly(ADP-ribose) Regulates microRNA activity and stress responses in the Cytoplasm. Mol Cell. 42:489-99.


    * Cover story, May 20, 2011 issue.


    * Selected by Faculty of 1000 as Must Read, Factor 8.0


    2. Leung, A.K., Young, G.A., Bhutkar, A.J. Zheng, G.X. and Sharp, P.A. 2011. Genomewide Identification of Endogenous Argonaute Binding sites in Mouse Embryonic Stem Cells with and without Mature microRNAs. Nature Struct. Mol. Biol. 18:237-44.