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Anthony K. L. Leung, PhD

Affiliate Member, Institute of McKusick-Nathans Genetic Medicine, Johns Hopkins School of Medicine

Assistant Professor

Departmental Affiliation(s):

Biochemistry and Molecular Biology

Contact Information

615 N. Wolfe Street, E8632, Baltimore, MD 21205
Baltimore , Maryland   21205
US        

+1 (410) 502 8939
+1 (410) 955 2926

www.leunglab.org: www.leunglab.org

SciVal Experts Research Profile

Education

PhD , 2003

Overview

 

My research program focuses on understanding the relationship between microRNAs and stress in cancers and mouse embryonic stem cells, using biochemical, cellular imaging and genomics approaches. Recently, I discovered that microRNA activity is regulated by poly(ADP-ribose), a "druggable" post-translational modification that is essential in multicellular organisms. Dysregulation in synthesis of poly(ADP-ribose) results in human diseases including cancers. My research program is to characterize how this post-translational affects the activities of RNA-mediated gene regulation and to test whether human diseases can be treated by inhibitors against poly(ADP-ribose) metabolism.

 

 

Honors and Awards

2011-2013 Idea Award, Department of Defense Breast Cancer Research Program

2007-2010 Special Fellowship, The Leukemia & Lymphoma Society

2004-2007 Long-term Fellowship, Human Frontier Science Program

Jul-Aug 2003 Travelling Fellowship, Journal of Cell Science, Company of Biologist Limited

Jun-Jul 2002 European Advanced Light Microscopy Facility Fellowship, EMBL Heidelberg, Germany

1999-2002 Scholarship, Croucher Foundation, Hong Kong

1999-2002 Overseas Research Scheme Award, UK

1995-1999 Waugh Scholarship, University of Oxford, UK

1995-1999 Fitzgerald Prize, University of Oxford, UK

Poly(ADP-ribose), microRNAs, Cancers, RNA regulation, RNA granules, stress responses, therapeutic siRNAs, high-resolution imaging, quantitative proteomics, bioinformatics

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    Journal Articles

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    1. Leung, A.K., Vyas, S., Rood, J.E., Bhutkar, A.J., Sharp, P.A. and Chang, P. Poly(ADP-ribose) Regulates microRNA activity and stress responses in the Cytoplasm. Mol Cell. 42:489-99.

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    * Cover story, May 20, 2011 issue.

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    * Selected by Faculty of 1000 as Must Read, Factor 8.0

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    2. Leung, A.K., Young, G.A., Bhutkar, A.J. Zheng, G.X. and Sharp, P.A. 2011. Genomewide Identification of Endogenous Argonaute Binding sites in Mouse Embryonic Stem Cells with and without Mature microRNAs. Nature Struct. Mol. Biol. 18:237-44.