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Kunihiro Matsushita, MD

Assistant Scientist

Departmental Affiliation(s):

Epidemiology

Center & Institute Affiliation(s):

Contact Information

615 N. Wolfe Street (Rm W6017), Baltimore, MD 21205
Baltimore , Maryland
US        

(443) 287-8766
(443) 683-8358

Education

MD , Nagoya University , 2007
PhD

Overview

Through my clinical experience as an interventional cardiologist, I was first interested in diabetes as a key risk factor for coronary heart disease and its antecedent, obesity. Thus, my early research area of interest was eplidemological relationship among insulin resistance, adipokines, inflammatory markers, and cardiovascular risk.

Since I came to JHSPH, I added a kidney angle to my research. I have been investigating the associations among kidney, diabetes, and cardiovascular disease associations using the Atherosclerosis Risk in Communities (ARIC) Study and a recently developed collaboration, Chronic Kidney Disease (CKD) Prognosis Consortium (http://www.jhsph.edu/ckdpc).

I have been also responsible for organizing all consortium activities in the CKD Prognosis Consortium as well as a key member of the Hopkins based analysis team. The Consortium is tasked with compiling and meta-analyzing the best available data to provide a more comprehensive evaluation of the impact of CKD on prognosis, with implications for improving the definition and staging of CKD. Eventually we formed an analysis committee which completed a meta-analysis of data from 45 cohorts including approximately 1.5 million participants with information on estimated glomerular filtration rate (eGFR), albuminuria and key CKD outcomes (mortality and a few kidney outcomes such as end-stage renal disease) in a year.

I am interested in establishing a bridge between clinical cardiology and cardiovascular epidemiology, contributing to better application of epidemiologic methods to clinical questions to form an evidence-base that can improve treatment and prevention of cardiovascular disease.

Honors and Awards

Honors

       2005 American College of Physician Membership

2007 Research Fellow of the Japan Society for the Promotion of Science

2013 Best Reviewers of the Year 2012 of the Annals of Internal Medicine

Awards

2004 Japanese Society of Interventional Cardiology Clinical Research Award

2005 Aichi Foundation for Daibetes, Rheumatic Disease and Gout Research Grant

2006 Takao Fund Travel Award.

2009 Early Career Travel Award from the American Heart Association Council on Epidemiology and Prevention

2009 The Aoyama-Kita Scholarship, Johns Hopkins Bloomberg School of Public Health

2013 Early Career Best Science Award for Abstract Poster Presentation at the American Heart Association Scientific Sessions 2013

2014 The Sandra Daugherty Award for Excellence in Cardiovascular Disease or Hypertension Epidemiology from the American Heart Association

epidemiology, cardiovascular disease, kidney disease, diabetes, obesity, adipokines

    Representative publications:

  • Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, Gansevoort RT for the Chronic Kidney Disease Prognosis Consortium. Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality: a collaborative meta-analysis of 21 general population cohorts.  Lancet. 2010;375:2073-81.

  • Matsushita K, Blecker S, Pazin-Filho A, Bertoni A, Chang PP, Coresh J, Selvin E. The Association of Hemoglobin A1c with Incident Heart Failure among Persons without Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study. Diabetes. 2010;59:2020-6.

  • Matsushita K, Mahmoodi BK, Woodward M, Emberson JR, Jafar T, Jee SH, Polkinghorne KR, Shankar A, Smith DH, Tonelli M, Warnock DG, Wen CP, Coresh J, Gansevoort RT, Hemmelgarn BR, Levey AS for the Chronic Kidney Disease Prognosis Consortium. Comparison of risk prediction using the CKD-EPI equation and the MDRD Study equation for estimated glomerular filtration rate. JAMA. 2012;307:1941-1951.

  • Hui X, Matsushita K, Sang Y, Ballew SH, Fülöp T, Coresh J. CKD and Cardiovascular Disease in the Atherosclerosis Risk in Communities (ARIC) Study: Interactions With Age, Sex, and Race. Am J Kidney Dis. 2013;62:691-702.

  • Matsushita K, Sang Y, Ballew SH, Astor BC, Hoogeveen RC, Solomon SD, Ballantyne CM, Woodward M, Coresh J. Cardiac and Kidney Markers for Cardiovascular Prediction in Individuals With Chronic Kidney Disease: The Atherosclerosis Risk in Communities Study. Arterioscler Thromb Vasc Biol. 2014 May 29. [Epub ahead of print]