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Kunihiro Matsushita, MD

Assistant Scientist

Departmental Affiliation(s):

Epidemiology

Contact Information

615 N. Wolfe Street (Rm W6017), Baltimore, MD 21205
Baltimore , Maryland
US        

(443) 287-8766
(443) 683-8358

Education

MD , Nagoya University , 2007
PhD

Overview

Through my clinical experience as an interventional cardiologist, I was first interested in diabetes as a key risk factor for coronary heart disease and its antecedent, obesity. Thus, my early research area of interest was eplidemological relationship among insulin resistance, adipokines, inflammatory markers, and cardiovascular risk.

Since I came to JHSPH, I added a kidney angle to my research. I have been investigating the associations among kidney, diabetes, and cardiovascular disease associations using the Atherosclerosis Risk in Communities (ARIC) Study and a recently developed collaboration, Chronic Kidney Disease (CKD) Prognosis Consortium (http://www.jhsph.edu/ckdpc).

I have been also responsible for organizing all consortium activities in the CKD Prognosis Consortium as well as a key member of the Hopkins based analysis team. The Consortium is tasked with compiling and meta-analyzing the best available data to provide a more comprehensive evaluation of the impact of CKD on prognosis, with implications for improving the definition and staging of CKD. Eventually we formed an analysis committee which completed a meta-analysis of data from 45 cohorts including approximately 1.5 million participants with information on estimated glomerular filtration rate (eGFR), albuminuria and key CKD outcomes (mortality and a few kidney outcomes such as end-stage renal disease) in a year.

I am interested in establishing a bridge between clinical cardiology and cardiovascular epidemiology, contributing to better application of epidemiologic methods to clinical questions to form an evidence-base that can improve treatment and prevention of cardiovascular disease.

Honors and Awards

Honors

2005 American College of Physician Membership

2007 Research Fellow of the Japan Society for the Promotion of Science

 

Awards

2004 Japanese Society of Interventional Cardiology Clinical Research Award

2005 Aichi Foundation for Daibetes, Rheumatic Disease and Gout Research Grant

2006 Takao Fund Travel Award.

2009 Early Career Travel Award from the American Heart Association Council on Epidemiology and Prevention

2009 The Aoyama-Kita Scholarship, Johns Hopkins Bloomberg School of Public Health

epidemiology, cardiovascular disease, kidney disease, diabetes, obesity, adipokines

  • Representative publications:

    1. Matsushita K, Mahmoodi BK, Woodward M, Emberson JR, Jafar T, Jee SH, Polkinghorne KR, Shankar A, Smith DH, Tonelli M, Warnock DG, Wen CP, Coresh J, Gansevoort RT, Hemmelgarn BR, Levey AS for the Chronic Kidney Disease Prognosis Consortium. Comparison of risk prediction using the CKD-EPI equation and the MDRD Study equation for estimated glomerular filtration rate. JAMA.2012;307:1941-1951.
    2. Matsushita K, Tonelli, M, Lloyd A, Levey AS, Coresh J, Hemmelgarn BR, for the Alberta Kidney Disease Network. Clinical Risk Implications of the CKD-EPI Equation Compared to the MDRD Study Equation for Estimated Glomerular Filtration Rate. Am J Kidney Dis. 2012 May 4. [Epub ahead of print]
    3. Waheed S, Matsushita K, Sang Y, Hoogeveen R, Ballantyne C, Coresh J, Astor BC. Combined Association of Albuminuria and Cystatin C-Based Estimated GFR With Mortality, Coronary Heart Disease, and Heart Failure Outcomes: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Kidney Dis. 2012 Apr 24. [Epub ahead of print]
    4. Bower JK, Appel LJ, Matsushita K, Young JH, Alonso A, Brancati FL, Selvin E. Glycated Hemoglobin and Risk of Hypertension in the Atherosclerosis Risk in Communities Study. Diabetes Care. 2012;35:1031-7.