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Lucian Soane, MD

Research Associate

Departmental Affiliation(s):

Molecular Microbiology and Immunology

Contact Information

615 North Wolfe Street, W5102
Baltimore , Maryland   21205
US        

410-614-3110
410-955-0105

Education

MD , University of Medicine and Pharmacy School of Medi , 1995

Overview

Programmed cell death (Apoptosis); Mitochondria; Physiopathology of neurodegenerative diseases and acute brain injury; Molecular mechanisms of neural cell death; Molecular Immunology, Complement system

Apoptosis, Mitochondria, Neurodegeneration, Acute Brain injury, Neural cell death , Complement system

  • Book Chapters

    Soane L., Solenski N., Fiskum G. (2006). Mitochondrial mechanisms of oxidative stress and apoptosis. Chapter 6.5 in Handbook of Neurochemistry and Molecular Neurobiology, Brain Energetics. Integration of Molecular and Cellular Processes(Lajtha A., Gibson G., Dienel G., editors). Springer, Berlin Heidelberg.

  • In Press: Soane L., Polster B.M., and Fiskum, G. (2010). Mitochondrial Mechanisms of Neural Cell Death in Cerebral Ischemia. Chapter 14 in Apoptosis: Physiology and Pathology, (John C. Reed and Douglas R. Green, Eds.), Cambridge University Press. 

  • Journal Articles

    Badea T.C., Niculescu F., Soane L., Shin M.L., Rus H. (1998) Molecular cloning and characterization of RGC-32 a novel gene induced by complement activation in oligodendrocytes. J. Biol. Chem. 273, 26977-26981.

  • Niculescu F., Soane L., Badea T., Shin M.L., Rus H. (1999) Tyrosine phosphorylation and activation of Janus kinase 1 and STAT 3 by sublytic C5b-9 complement complex in aortic endothelial cells. Immunopharmacology 42, 187-193.

  • Soane L., Rus H., Niculescu F., Shin M.L. (1999) Inhibition of oligodendrocyte apoptosis by sublytic C5b-9 is associated with enhanced synthesis of Bcl-2 and inhibition of caspase-3 activation. J. Immunol.163, 6132-6138.