Daniela Drummond-Barbosa, PhD
PhD , 1995
Stem cells respond to a variety of physiological stimuli, including dietary changes. Yet, the underlying molecular and cellular mechanisms are poorly understood. Over the past several years, we have been exploring the question of how ovarian stem cells and their descendents sense and respond to diet in Drosophila, a highly tractable genetic model system. What signals mediate the effects of diet? What organs, tissues and cell types generate and receive each signal? How they are seamlessly integrated to control egg output? These are some of the questions we are addressing using a combination of genetic, molecular, and cell biological tools.
Honors and Awards
1988 - First place in college entrance exam for Biological Sciences, Universidade Federal de Minas Gerais (Brazil)
1990-1991 - Scientific Initiation Fellowship, Conselho Nacional de Pesquisas (Brazil)
1993-1995 - Miles Scholar Award, Bayer Corporation
1997-2000 - National Research Service Award, National Institutes of Health
2006 - Chancellor’s Award for Research, Vanderbilt University
2008 - Semifinalist, 2009 Early Career Scientist Competition, Howard Hughes Medical Institute
2009 - Invited Plenary Lecture, 50th Annual Drosophila Research Conference, Chicago, IL
2007-2011 - American Cancer Society Research Scholar
2014 - Elected as a fellow of the American Association for the Advancement of Science (AAAS)
Research Keywords Stem cells, reproduction, fertility, oogenesis, diet, insulin, TOR, steroids, Drosophila, developmental biology, endocrinology, physiology, genetics
Ables, E. T., Bois, K. E., Garcia, C. A., Drummond-Barbosa, D. Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila. Developmental Biology (in press).
Laws, K., Sampson, L. L., Drummond-Barbosa, D. Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance. Developmental Biology (in press).
Armstrong, A. R., Laws, K., Drummond-Barbosa, D. Adipocyte amino acid sensing controls adult germline stem cell number via the amino acid response pathway and independently of Target of Rapamycin signaling in Drosophila. Development 141: 4479-4488, 2014.
Ables, E., Drummond-Barbosa, D. Cyclin E controls Drosophila female germline stem cell maintenance independently of its roles in proliferation by modulating responsiveness to niche signals. Development 140:530-540, 2013.
Ables, E. T., Laws, K., Drummond-Barbosa, D. Control of adult stem cells in vivo by a dynamic physiological environment: diet-dependent systemic factors in Drosophila and beyond. WIREs Dev. Biol. 1:657-674, 2012. Doi: 10.1002/wdev.48
Most recent publications: