PhD, Johns Hopkins University, 1972
Brief description of current research activities:
My research interests are focused on the structural basis of physiologic lung function and how this normal structure manifests itself in pathologic situations and environmental exposures. Current work is concerned with understanding the mechanisms that underlie the chronic lung tissue destruction that occurs in emphysema. These functional and immunological studies in the mouse are directed toward investigating mechanisms of alveolar destruction with age or with emphysematous lesions. How this tissue destruction impacts the interaction between the lung parenchyma and airways plays a key role in the ability to breath in this pathology, and ongoing work is involved in studying this interaction. Additional funded work involves evaluating methods of impairing the ability of airway smooth muscle to shorten, as a possible treatment of asthma. The approach, termed bronchial thermoplasty, has direct clinical implications for the most severe asthmatic subjects. I also have a keen interest in understanding and developing methods to properly phenotype pulmonary function in the mouse, which is the most common experimental animal model of most human diseases. I’ve chaired several minisymposia and postgraduate courses in this area of mouse phenotyping.
Honors and Awards
Member of Tau Beta Pi, Eta Kappa Nu, & Sigma XI Honor Societies
1975 - 1978. Recipient of Young Investigator Pulmonary Research Grant
1978 - 1982. Recipient of NIH Research Career Development Award
1983 - 1993. Editorial Board of American Review of Respiratory Disease
1983 - present. Editorial Board of Journal of Applied Physiology
1996 Elected to the College of Fellows of the American Institute of Medical and Biological Engineering
2000. Distinguished Service Award from the American Lung Association of Maryland.
2006. Joseph Rodarte Award for Achievements in Respiratory Medicine and Physiology, awarded by the American Thoracic Society
2006 - 2008. Chair of Respiratory Structure & Function Assembly of the American Thoracic Society.
2007 - 2009. Chair of NIH study section on Respiratory integrative Biology and Translation
2010 - present. Consulting Editor, Journal of Applied Physiology