Steven An, PhD
- Associate Professor
615 N. Wolfe Street
Baltimore, Maryland 21205
Molecular Biophysics and Cellular Mechanics Lab of Dr. An: http://www.jhsph.edu/departments/environmental-health-sciences/an/
PhD, Brown University, 2000
MS, Albany Medical College, 1995
My current work comprises both basic and translational research focusing on the cellular and molecular basis for obstructive lung diseases and exploring new intervention strategies. Molecular targets include: 1) HSP20; 2) Nrf2 pathways; and 3) novel G-protein coupled receptor expression, signaling and function in the lung.
My lab has the unique capability to measure, at the single cell level, changes in stiffness using Magnetic Twisting Cytometry (MTC), contractile force using Fourier Transform Traction Microscopy (FTTM), and discrete molecular-level remodeling dynamics of the living cytoskeleton using Spontaneous Nanoscale Tracer Motions (SNTM). These state-of-art nanotechnologies are readily applicable to a wide variety of cell types and, in combination of multiple genetic, chemical and mechanical manipulations, have broad research applications that are at the interface of cell biology, physics and medicine.
An lab is supported by grants from National Institutes of Health: P01HL114471, R01HL107361, R01HL058506, R01AG041265, R01DK035385, and R01ES024784.
Honors and Awards
Ann Woolcock Memorial Award for Outstanding Contributions and Future Promise in Asthma Research, American Thoracic Society, 2006
Faculty Research Initiative Fund Award, Johns Hopkins University, 2007
American Asthma Foundation (Sandler) Award, 2010-2013
Pilot Grant from Johns Hopkins Engineering in Oncology Center at the Institute for NanoBioTechnology, 2011
Developmental Project Award, the Johns Hopkins University In Vivo Cellular and Molecular Imaging Center (ICMIC), School of Medicine, 2011 & 2013
Teaching Excellence, Johns Hopkins Bloomberg School of Public Health, 2012 & 2013
Chairperson, Cardiovascular and Respiratory Sciences Integrated Review Group, Center for Scientific Review Special Emphasis Panel, May 2013
Program Chair-Elect, Respiratory Structure and Function Assembly, American Thoracic Society, 2013
Program Chair, Respiratory Structure and Function Assembly, American Thoracic Society, 2014
Chairperson, Respiratory Integrative Biology and Translational Research Study Section, Center for Scientific Review Special Emphasis Panel, March 2015
- Airway Hyperresponsivenss in Asthma Airway Smooth Muscle Cell Mechanics Cytoskeleton Nanotechnologies Cancer Metabolism Aging
An SS, Fabry B, Trepat X, Wang N, and Fredberg JJ. (2006) Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol. 35:55-64.
Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, and Fredberg JJ (2007) Universal physical responses to stretch in the living cell. Nature 447:592-595.
Deshpande DA, Wang WCH, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JSK, and Liggett SB (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nature Medicine 16:1299-1304.
Deshpande DA, Robinett KS, Wang WC, Sham JS, An SS, and Liggett SB (2011) Reply to: Bronchodilator activity of bitter tastants in human tissues. Nature Medicine 17:716-778.
An SS, Robinett KS, Deshpande DA, Wang WC, and Liggett SB (2012) Reply to: Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nature Medicine 18:648-651.
Garzon-Muvdi T, Schiapparelli P, Ap Rhys CM, Guerrero-Cazares H, Smith C, Kim DH, Kone L, Farber H, An SS, Levchenko A, and Quinones-Hinojosa A. (2012) Regulation of brain tumor dispersal by NKCC1 through a novel role in focal adhesion regulation. PLoS Biology 10(5):e1001320.
Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Ungvari Z, Herbert RL, Tilmont EM, Pearson KJ, Lakatta EG, and de Cabo R. (2014) Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates. Cell Metabolism 20:183-190.
Moon YW, Rao G, Kim J, Shim HS, Park KS, An SS, Kim B, Steeg PS, Sarfaraz S, Lee C, Voeller D, Choi EY, Luo J, Palmieri D, Chung HC, Kim JH, Wang Y, and Giaccone G. LAMC2 enhances metastatic potential in lung adenocarcinoma. Cell Death & Differentiation (In Press).
We are currently looking for talented students and post-doctoral fellows to join our efforts to elucidate the pathogenesis of obstructive lung diseases, central aterial stiffening induced by diet and aging, and metastatic-invasion of cancer (spanning brain, breast, lung, melanoma and prostate).