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Qian-Li Xue, PhD

Core Faculty, Center on Aging and Health

Associate Professor

Departmental Affiliation(s):

School of Medicine (Primary)
Epidemiology (Joint)
Biostatistics (Joint)

Center & Institute Affiliation(s):

Contact Information

2024 E. Monument Street
Suite 2-700
Baltimore , Maryland
US        

410-502-7808
410-614-9625

Education

PhD

Overview

My primary area of statistical expertise is the development and application of statistical methods for (i) handling truncation of information on underlying or unobservable outcomes (e.g., disability) as a result of screening, (ii) missing data including outcome (e.g. frailty) censoring by a competing risk (e.g. mortality), and (iii) trajectory analysis of multivariate outcomes. Other areas of methodologic research interests include multivariate, latent variable models.

In Women's Health and Aging Studies, I have closely collaborated with scientific investigators on the design and analysis of longitudinal data relating biomarkers of inflammation, hormonal dysregulation, and micronutrient deficiencies to the development and progression of frailty and disability, as well as characterizing the natural history of change in cognitive and physical function over time.

Honors and Awards

2000 Student Paper Award from the International Biometrics Society Eastern North American Region

2007 Travel Award, Conference on Biomarkers of Aging, American Federation of Aging Research

2010-2011 Nathan Shock Scholar, the Nathan W. and Margaret T. Shock Aging Research Foundation

Epidemiology,Epidemiological design; latent variable; longitudinal data; measurement error; missing data; multivariate categorical data

    Selected publications from the last five years

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    Xue QL, Bandeen-Roche K, Mielenz, TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Varadhan R, Yao WL, Fried LP. Patterns of 12-Year Change in Physical Activity in Community-Dwelling Older Women: Can Modest Levels of Physical Activity Help Older Women Live Longer? Am J Epidemiol. 2012 Sep 15;176(6):534-43. Epub 2012 Aug 30. PMID:22935515

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    Xue QL, Beamer BA, Chaves PHM, Guralnik JM, Fried LP. Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: The Women’s Health and Aging Study II. J Am Geriatr Soc. 2010 Nov;58(11):2076-84. PMID: 21054287

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    Xue QL, Walston JD, Fried LP, Beamer BA. Rate of decline in grip strength predicts the risk of falling, physical disability, and frailty: The Women’s Health and Aging Study. Arch Intern Med. 2011 Jun;171(12): 1119:1121. PMID: 21709116

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    Fried LP, Xue QL, Cappola A, Chaves PHM, Ferrucci L, Leng S, Semba RD, Varadhan R, Walston JD, Bandeen-Roche K. Nonlinear Multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1049-57. PMID: 19567825

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    Xue QL, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-space constriction, development of frailty, and the competing risk of mortality: The Women’s Health and Aging Study I. Am J Epidemiol. 2008; 167(2):240-48. PMID: 17906296