Wen Hong Linda Kao,
My research interest is the epidemiology of diabetes and related conditions. My collaborators and I have conducted several population-based studies nested within the Atherosclerosis Risk in Communities Study and the Third National Health and Nutritional Examination Survey (NHANES III) to examine environmental and genetic (candidate gene and admixture mapping) risk factors for the development of obesity, type 2 diabetes, and chronic kidney disease. I also currently have two NIH-funded studies to perform admixture mapping analyses in the ARIC study and the FIND Study (Family Investigation of Diabetes and Nephropathy). In terms of family-based genetic analyses, I have a project studying the genetic epidemiology of non-alcoholic fatty liver disease (NAFLD) in about 1,000 individuals, from about 30 3-generational families, from Lancaster, Pennsylvania. For each of these projects, we are using genome-wide SNP arrays and sequence data to identify susceptibility loci for these complex traits. Lastly, I also have a prospective cohort study of about 500 incident dialysis patients where we are studying risk factors for sudden cardiac death.
Honors and Awards
2000 Michaela Modan Award (American Diabetes Association) 1999 Jean Comb Award (JHBSPH) 1998 Induction to Delta Omega Honorary Society (JHBSPH) 1997 Jean Comb Award (JHBSPH) 1997 Delta Omega Honorary Society Alpha Chapter Poster Competition-first prize
- Chronic kidney disease
- Genetic epidemiology
- Admixture mapping
- Non-alcoholic fatty liver disease
Cheng CY, Kao WHL, Patterson N, Tandon A, Haiman CA, Harris TB, Xing C, John EM, Ambrosone CB, Brancati FL, Coresh J, Press MF, Parekh RS, Klag MJ, Meoni LA, Hsueh WC, Fejerman L, Pawlikowska L, Freedman ML, Jandorf LH, Bandera EV, Ciupak GL, Nalls MA, Akylbekova EL, Orwoll ES, Leak TS, Miljkovic I, Li R, Ursin G, Bernstein L, Ardlie K, Taylor HA, Boerwinckle E, Zmuda JM, Henderson BE, Wilson JG, Reich D. Admixture mapping of 15,280 African Americans identifies obesity susceptibility Loci on chromosomes 5 and X. PLoS Genet. 2009 May;5(5):e1000490. Epub 2009 May 22.
Köttgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, Smith AV, Arking DE, Astor BC, Boerwinkle E, Ehret GB, Ruczinski I, Scharpf RB, Ida Chen YD, de Boer IH, Haritunians T, Lumley T, Sarnak M, Siscovick D, Benjamin EJ, Levy D, Upadhyay A, Aulchenko YS, Hofman A, Rivadeneira F, Uitterlinden AG, van Duijn CM, Chasman DI, Paré G, Ridker PM, Kao WHL, Witteman JC, Coresh J, Shlipak MG, Fox CS. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet. 2009 May 10. [Epub ahead of print]
Kao WHL‡ Arking DE‡, PhD, Post W‡,Rea T, Sotoodehnia N, Prineas RJ, Bishe B, Doan B, Boerwinkle E, Psaty BM, Tomaselli G, Coresh J, Siscovick DS, Márban E, Spooner PM, Burke G, Chakravarti A. Genetic Variations in NOS1AP Predict Sudden Cardiac Death in the General U.S. Population. Circulation. 2009 Feb 24; 119(7): 940-51. Epub 2009 Feb 9.
Post W, Shen H, Damcott C, Arking DE, Kao WHL, Sack PA, Ryan KA, Chakravarti A, Mitchell BD, Shuldiner AR. Associations between Genetic Variants in the NOS1AP (CAPON) Gene and Cardiac Repolarization in the Old Order Amish. Hum Hered. 2007;64(4):214-9. Epub 2007 Jun 12.
Kao WHL‡, Klag MJ‡, Meoni LA, Reich D, Berthier-Schaad Y, Li M, Coresh J, Patterson N, Tandon A, Powe NR, Fink NE, Sadler JH, Weir MR, Abboud HE, Adler SG, Divers J, Iyengar SK, Freedman BI, Kimmel PL, Knowler WC, Kohn OF, Kramp K, Leehey DJ, Nicholas SB, Pahl MV, Schelling JR, Sedor JR, Thornley-Brown D, Winkler CA, Smith MW, Parekh RS; on behalf of the Family Investigation of Nephropathy and Diabetes (FIND) Research Group. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet. 2008 Sep 14. [Epub ahead of print]