Clarke G. Tankersley, PhD
Division of Physiology, Rm E7612 (office), Rm E6609 and E6613 (lab)
Baltimore , Maryland
410-614-8283 (office), 41
PhD , Pennsylvania State University , 1991
ScD , Johns Hopkins University
My research attention is focused on the control of ventilation and how genetic predisposition may facilitate individual susceptibility to air-borne toxins. These interests emphasize the identification of specific major and modifying genes that determine normal breathing pattern and the control of ventilation during hypercapnic and hypoxic exposures. The strength and success of this research endeavor is found in the unique, multidisciplinary approach utilizing inbred murine strains to model physiological systems affected by heredity in human populations. For example, these experiences have led us to better understand the changes in respiratory function associated with amyotrophic lateral sclerosis (ALS). My training is consistent with an integrated systems physiological approach, and my educational scope is comprised of topics concerning aging and environmental stress as these pertain to cardiovascular, reproductive and thermoregulatory mechanisms in humans. My career goals also include a strong commitment to teaching and directly interacting with graduate, undergraduate honors, and minority underrepresented students. In addition, I am dedicated to collaborating with research associates and other community professionals.
Honors and Awards
1991-1992 Phi Kappa Phi Honor Society
1993-1994 National Research Service Award
1996-2000 First Independent Research Support and Transition Award
1997-2000 Co-Chairperson: American Thoracic Society Workshop Committee on Inheritance and Ventilatory Control
2000-2001 Chairperson: American Physiological Society Symposium: Physiological Genomics of the Respiratory System
2000 Keynote Speaker: American Thoracic Society Symposium: Obesity and Sleep Apnea
2001 Co-Chairperson: American Thoracic Society Symposium: Genetic, Central and Peripheral Influences of Breathing
2001 Co-Chairperson: American Thoracic Society Symposium: Genetic Dissection of Ventilatory Traits
2002 Co-Chairperson: American Thoracic Society Symposium: Neural Development and Genetic Influence of Apnea Genesis
2002-2004 Chairperson: American Thoracic Society Respiratory, Neurobiology and Sleep Planning Committee
- Environmental Health Sciences
- Environmental Stress Physiology
- Mouse Genetics
- Pulmonary Physiology
- Linkage Analysis
- Control of Ventilation
- Genetic Susceptibility
- Air Pollutant Toxicology
- Respiratory Effects of ALS
- and Genetic Obesity
Tankersley, C.G., R. Rabold, and W.A. Mitzner. Differential lung mechanics are genetically determined in inbred murine strains. Journal of Applied Physiology. 86(6): 1764-1769, 1999.
O'Donnell, C.P., C.G. Tankersley, V.P. Polotsky, A.R. Schwartz, and P.L. Smith. Leptin, obesity and respiratory function. Respiration Physiology. 119: 163-170, 2000.
Tankersley, C.G., R.C. Elston and A.H. Schnell. Genetic determinants of acute hypoxic ventilation: Patterns of inheritance in mice. Journal of Applied Physiology. 88: 2310-2318, 2000.
Tankersley, C.G. Variation in acute hypoxic ventilatory response is linked to mouse chromosome 9. Journal of Applied Physiology. (Selected Contribution). 90(4): 1615-1622, 2001.
Soutiere, S.E. and C.G. Tankersley. Challenges implicit to gene discovery research in the control of ventilation during hypoxia. High Altitude Medicine and Biology. Summer. 2(2):191-200. 2001.