Johns Hopkins Asthma & Allergy Center, 4B.77
Baltimore , Maryland
1) Hypoxic Pulmonary Vasoconstriction. The acute pulmonary vasoconstrictor response to hypoxia optimizes local oxygen exchange in normal lungs, but can contribute to pulmonary hypertension, corpulmonale, and mortality in patients with diffuse lung disease or in subjects exposed to high altitude. My work seeks to promote understanding of in vivo hypoxic pulmonary vasoconstriction by clarifying the mechanisms responsible for direct effects of hypoxia on pulmonary arteries, arterial myocytes, and arterial endothelium observed in vitro. 2) Ischemia-Reperfusion Injury in Isolated Lungs. These studies will attempt to determine the mechanisms by which ischemia and reperfusion injure the isolated lung and whether these mechanisms are relevant to ischemia-reperfusion lung injury in in vivo animals.
- Hypoxic Pulmonary Vasoconstriction
- Ischemia-Reperfusion Injury in Isolated Lungs
Wiener CM, MR Banta, NA Flavahan, JT Sylvester. Mechanisms of hypoxic vasodilation in ferret pulmonary arteries. Am J Physiol 13:L351-357, 1995.
Pearse DB and JT Sylvester. Vascular injury in isolated sheep lungs. Am J Resp Crit Care Med 153:196-202, 1996.
Shanholtz C, P White Jr, S Permutt, JT Sylvester, T Permutt, R Brower. Assessment of protein permeability in th normal human systemic circulation. (Submitted, J Clin Invest, 9/96.)
Becker PM, JT Sylvester, WL Buchanan, AMK Choi. Effects of ischemia on antioxidant enzyme expression in ventilated ferret lungs.