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Elizabeth A. Platz, ScD

Martin D. Abeloff, MD Scholar in Cancer Prevention

Deputy Chair, Department of Epidemiology

Director, Cancer Epidemiology, Prevention, & Control Training Program

Leader, Cancer Prevention & Control Program, SKCCC

Professor

Departmental Affiliation(s):

Epidemiology
School of Medicine (Joint)

Center & Institute Affiliation(s):

Contact Information

615 N. Wolfe Street
Room 6132
Baltimore , Maryland   21205
US        

410-614-9674
(410) 614-2632

SciVal Experts Research Profile

Education

ScD , Harvard University , 1995
MPH , Yale University , 1989

Overview

Dr. Platz is a cancer epidemiologist, whose research on prostate and colon cancers sits at the interface between epidemiology and basic science. Within prospective cohorts, she studies the association of genetic and epigenetic factors as well as circulating markers of androgenicity, inflammation, and oxidation with prostate cancer incidence and recurrence. For colorectal neoplasia, her work focuses on the metabolic syndrome, growth factors, and inflammation as sequelae of adiposity. She also studies the role of modifiable factors that influence these pathways, such as diet and lifestyle, in relation to the incidence of these diseases and other men’s health concerns. In addition, she studies these factors in association with benign conditions of the prostate and colon, including benign prostatic hyperplasia and adenomatous polyps. She has a long-standing interest uncovering explanations for the notably higher rate of prostate cancer in African-American compared to white men, including racial variation in sex steroid hormones in the in utero milieu and throughout life. Dr. Platz conducts her multidisciplinary work with an eye toward translation; that is, identifying strategies to prevent the development or progression of cancer. These goals have led to her recent research interest in the possible benefits of drugs for other indications, including statin drugs, as well as their underlying mechanisms of action in the prevention of the development and recurrence of prostate cancer. Finally, she dabbles in research that identifies and solves methodologic issues in study design germane to epidemiologic and translational studies on prostate cancer detection, incidence, prognosis, and recurrence.

Honors and Awards

Faculty Innovation Fund

Bernstein Young Investigator's Award

Delta Omega Honorary Society in the Public Health Alpha Chapter

2003 and 2007 AMTRA Award (recognition for advising, mentoring and teaching)

2010 Martin D. Abeloff, MD Scholar in Cancer Prevention (First), Sidney Kimmel Comprehensive Cancer Center (honoring the memory of Dr. Abeloff, late Director of the Cancer Center)

Epidemiology, prostate cancer incidence and recurrence, benign prostatic hyperplasia, colorectal cancer, adenomatous polyps, diet, lifestyle, race, genetics, epigenetics, telomeres, inflammation, insulin, obesity, sex steroid hormones, vitamin D

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    Heaphy CM, Yoon GS, Peskoe SB, Joshu CE, Lee TK, Giovannucci E, Mucci LA, Kenfield SA, Stampfer MJ, Hicks JL, De Marzo AM, Platz EA, Meeker AK. Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death. Cancer Discov. 2013 Oct;3(10):1130-41. PMID: 23779129; PMCID: PMC3797255.

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    Mondul AM, Giovannucci E, Platz EA. A Prospective Study of Obesity, and the Incidence and Progression of Lower Urinary Tract Symptoms. J Urol. 2013 Sep 25.pii: S0022-5347(13)05477-3. doi: 10.1016/j.juro.2013.08.110. [Epub ahead of print] PubMed PMID: 24076306.

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    Platz EA, Yegnasubramanian S, Liu JO, Chong CR, Shim JS, Kenfield SA, Stampfer MJ, Willett WC, Giovannucci E, Nelson WG. A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment. Cancer Discov. 2011 Jun;1(1):68-77. PMID: 22140654; PMCID: PMC3227223.

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    Dluzniewski PJ, Wang MH, Zheng SL, De Marzo AM, Drake CG, Fedor HL, Partin AW, Han M, Fallin MD, Xu J, Isaacs WB, Platz EA. Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence. Cancer Epidemiol Biomarkers Prev. 2012 Oct;21(10):1774-82. PMID: 22859398;  PMCID: PMC3467312.

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    Joshu CE, Mondul AM, Menke A, Meinhold C, Han M, Humphreys EB, Freedland SJ, Walsh PC, Platz EA. Weight gain is associated with an increased risk of prostate cancer recurrence after prostatectomy in the PSA era. Cancer Prev Res (Phila). 2011 Apr;4(4):544-51. PMID: 21325564; PMCID: PMC3072036.